| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5138942 | B | Inhibition of recombinant human PRMT1 assessed as residual activity at 100 uM using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in presence of SAM by AlphaLISA method relative to control | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 2. | ALA5138944 | B | Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 3. | ALA5138945 | B | Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 4. | ALA5138946 | B | Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 5. | ALA5138947 | B | Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 6. | ALA5138948 | B | Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 7. | ALA5138949 | B | Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 8. | ALA5138950 | B | Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 9. | ALA5138951 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 10. | ALA5138952 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 11. | ALA5138953 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 12. | ALA5138954 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 13. | ALA5138955 | B | Selectivity index, ratio of IC50 for inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 14. | ALA5138956 | B | Selectivity index, ratio of IC50 for human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate to IC50 for inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 15. | ALA5138963 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as dissociation constant by surface plasmon resonance | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 16. | ALA5138964 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as binding constant (Kon) by surface plasmon resonance analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 17. | ALA5138965 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as binding constant (Koff) by surface plasmon resonance analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 18. | ALA5138966 | B | Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as in vitro residence time by surface plasmon resonance analysis | Homo sapiens | 9 | single protein format | Scientific Literature |
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