# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5122248 | B | Inhibition of GST-tagged TNKS1 (1023 - 1327 residues) (unknown origin) by ELISA | Homo sapiens | 1 | ALA5120795 | single protein format | Scientific Literature | |
2. | ALA5122249 | B | Inhibition of GST-tagged TNKS2 (873 - 1166 residues) (unknown origin) by ELISA | Homo sapiens | 1 | ALA5120795 | single protein format | Scientific Literature | |
3. | ALA5122250 | B | Inhibition of PARP1 (unknown origin) by fluorescence based multimode plate reader method | Homo sapiens | 1 | ALA5120795 | single protein format | Scientific Literature | |
4. | ALA5122251 | B | Inhibition of PARP2 (unknown origin) by fluorescence based multimode plate reader method | Homo sapiens | 1 | ALA5120795 | single protein format | Scientific Literature | |
5. | ALA5228272 | B | Inhibition of TNKS1 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 1 hr by ELISA | Homo sapiens | 24 | ALA5226325 | single protein format | Scientific Literature | |
6. | ALA5228273 | B | Modulation of Wnt/beta-catenin signaling pathway in human DLD-1 cells assessed as induction of AXIN2 accumulation incubated for 24 hrs by ELISA | Homo sapiens | 24 | ALA5226325 | cell-based format | Scientific Literature | |
7. | ALA5228274 | P | Solubility of compound at pH 7.4 | 24 | ALA5226325 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5228275 | A | Thermodynamic solubility in FaSSIF at pH 6.5 | 1 | ALA5226325 | assay format | Scientific Literature | ||
9. | ALA5228276 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance per mg of protein by UPLC analysis | Homo sapiens | 23 | ALA5226325 | microsome format | Scientific Literature | |
10. | ALA5228277 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance per mg of protein by UPLC analysis | Mus musculus | 24 | ALA5226325 | microsome format | Scientific Literature | |
11. | ALA5228278 | B | Inhibition of TNKS2 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 1 hr by ELISA | Homo sapiens | 23 | ALA5226325 | single protein format | Scientific Literature | |
12. | ALA5228279 | B | Inhibition of PARP-1 (unknown origin) using biotinylated NAD and NAD as substrate assessed as inhibition of auto-PARsylation incubated for 150 mins by TR-FRET assay | Homo sapiens | 23 | ALA5226325 | single protein format | Scientific Literature | |
13. | ALA5228280 | P | Lipophilicity, logD of compound at pH 7.4 | 12 | ALA5226325 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA5228281 | B | Selectivity index, ratio of IC50 for inhibition of PARP-1 (unknown origin) to IC50 for inhibition of TNKS1 (unknown origin) | Homo sapiens | 3 | ALA5226325 | assay format | Scientific Literature | |
15. | ALA5228282 | B | Selectivity index, ratio of IC50 for inhibition of PARP-1 (unknown origin) to IC50 for inhibition of TNKS2 (unknown origin) | Homo sapiens | 4 | ALA5226325 | assay format | Scientific Literature | |
16. | ALA5228283 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells at 1 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA5226325 | cell-based format | Scientific Literature | |
17. | ALA5228284 | A | Efflux ratio of apparent permeability across apical to basolateral over basolateral to apical side in human Caco-2 cells at 1 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA5226325 | cell-based format | Scientific Literature | |
18. | ALA5228285 | A | Clearance in mouse plasma | Mus musculus | 4 | ALA5226325 | cell-free format | Scientific Literature | |
19. | ALA5228286 | B | Binding affinity to recombinant human TNKS1 (1091 to 1327 residues) assessed as dissociation constant by ITC method | Homo sapiens | 3 | ALA5226325 | single protein format | Scientific Literature | |
20. | ALA5228287 | B | Inhibition of TNKS1 (unknown origin) | Homo sapiens | 1 | ALA5226325 | single protein format | Scientific Literature |