| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5161143 | A | Drug concentration in STZ-induced diabetic peripheral neuropathic mechanical allodynia in overnight fasted Sprague-Dawley rat spinal cord at 1 mg/kg, po measured at 5.75 hrs post dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 2. | ALA5161145 | B | Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs in presence of ATP by electrophoretic analysis | Homo sapiens | 55 | single protein format | Scientific Literature | ||
| 3. | ALA5161146 | B | Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis | Mus musculus | 47 | tissue-based format | Scientific Literature | ||
| 4. | ALA5161147 | B | Inhibition of full length human AAK1 expressed in HEK293F cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot analysis based cellular assay | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
| 5. | ALA5161148 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 51 | microsome format | Scientific Literature | ||
| 6. | ALA5161149 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 51 | microsome format | Scientific Literature | ||
| 7. | ALA5161150 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 51 | microsome format | Scientific Literature | ||
| 8. | ALA5161151 | A | Inhibition of CYP3A4 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 48 | single protein format | Scientific Literature | ||
| 9. | ALA5161152 | A | Volume of distribution at steady state in rat at 3 mg/kg,po or 2 mg/kg,iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA5161153 | A | Efflux ratio of permeability in human Caco-2 cells | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 11. | ALA5161158 | A | Ratio of drug concentration in spinal cord to plasma in CCI induced thermal hyperalgesia in Sprague-Dawley rat at 1 mg/kg, po measured at 5.5 hrs post dose | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA5161160 | A | Plasma concentration in CCI induced thermal hyperalgesia in Sprague-Dawley rat at 1 mg/kg, po measured at 5.5 hrs post dose | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA5161164 | A | Drug concentration in CCI induced thermal hyperalgesia in Sprague-Dawley rat spinal cord at 1 mg/kg, po measured after 5.5 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA5161166 | A | Half life in rat at 3 mg/kg, po or 2 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA5161167 | A | Total body clearance in rat at 3 mg/kg, po or 2 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA5161169 | A | Oral bioavailability in rat at 3 mg/kg or 2 mg/kg,iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA5161171 | T | Genotoxicity in Salmonella typhimurium by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | assay format | Scientific Literature | ||
| 18. | ALA5161190 | A | Plasma concentration in STZ-induced diabetic peripheral neuropathic mechanical allodynia in overnight fasted Sprague-Dawley rat at 1 mg/kg, po measured at 5.75 hrs post dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA5161191 | A | Ratio of drug concentration in spinal cord to plasma in STZ-induced diabetic peripheral neuropathic mechanical allodynia in overnight fasted Sprague-Dawley rat at 1 mg/kg, po measured at 5.75 hrs post dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA5161192 | A | Permeability of compound at pH 5.5 incubated for 4 hrs by PAMPA assay | 3 | assay format | Scientific Literature |
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