# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5161345 | Binding | Inhibition of recombinant human sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 mins for by fluorescence based assay | Homo sapiens | 9 | ALA5154790 | single protein format | Scientific Literature | |
2. | ALA5161346 | Binding | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 240 sec by Ellman's method | Homo sapiens | 9 | ALA5154790 | single protein format | Scientific Literature | |
3. | ALA5161347 | Binding | Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 240 sec by Ellman's method | Homo sapiens | 8 | ALA5154790 | single protein format | Scientific Literature | |
4. | ALA5161348 | Binding | Inhibition of recombinant mouse sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 mins for by fluorescence based assay | Mus musculus | 9 | ALA5154790 | single protein format | Scientific Literature | |
5. | ALA5161349 | Binding | Inhibition of recombinant mouse AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 240 sec by Ellman's method | Mus musculus | 9 | ALA5154790 | single protein format | Scientific Literature | |
6. | ALA5161350 | ADME | Permeability of the compound by PAMPA-BBB assay | 4 | ALA5154790 | assay format | Scientific Literature | ||
7. | ALA5161351 | Physicochemical | Kinetic aqueous solubility of the compound in DMSO/phosphate buffered saline incubated for 2 hrs by NEPHELOstar plus analysis | 4 | ALA5154790 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5161352 | Toxicity | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by propidium iodide staining based fluorescence analysis | Homo sapiens | 4 | ALA5154790 | cell-based format | Scientific Literature | |
9. | ALA5161353 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining measured after 1 hr in presence of NADP by UPLC-MS/MS analysis | Homo sapiens | 4 | ALA5154790 | microsome format | Scientific Literature | |
10. | ALA5161354 | ADME | Metabolic stability in human liver microsomes assessed as half life measured upto 60 mins in presence of NADP by UPLC-MS/MS analysis | Homo sapiens | 4 | ALA5154790 | microsome format | Scientific Literature | |
11. | ALA5161355 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance measured upto 60 mins in presence of NADP by UPLC-MS/MS analysis | Homo sapiens | 4 | ALA5154790 | microsome format | Scientific Literature | |
12. | ALA5161356 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining measured after 1 hr in presence of NADP by UPLC-MS/MS analysis | Mus musculus | 4 | ALA5154790 | microsome format | Scientific Literature | |
13. | ALA5161357 | ADME | Metabolic stability in mouse liver microsomes assessed as half life measured upto 60 mins in presence of NADP by UPLC-MS/MS analysis | Mus musculus | 4 | ALA5154790 | microsome format | Scientific Literature | |
14. | ALA5161358 | ADME | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance measured upto 60 mins in presence of NADP by UPLC-MS/MS analysis | Mus musculus | 4 | ALA5154790 | microsome format | Scientific Literature | |
15. | ALA5161359 | ADME | Metabolic stability in rat liver microsomes assessed as parent compound remaining measured after 1 hr in presence of NADP by UPLC-MS/MS analysis | Rattus norvegicus | 4 | ALA5154790 | microsome format | Scientific Literature | |
16. | ALA5161360 | ADME | Metabolic stability in rat liver microsomes assessed as half life measured upto 60 mins in presence of NADP by UPLC-MS/MS analysis | Rattus norvegicus | 4 | ALA5154790 | microsome format | Scientific Literature | |
17. | ALA5161361 | ADME | Metabolic stability in rat liver microsomes assessed as intrinsic clearance measured upto 60 mins in presence of NADP by UPLC-MS/MS analysis | Rattus norvegicus | 4 | ALA5154790 | microsome format | Scientific Literature |
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