# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5142716 | F | Anti-filarial activity against Onchocerca gutturosa adult worms assessed as reduction in worm motility measured every 24 hrs for 5 days by olympus inverted microscopic analysis | Onchocerca gutturosa | 60 | organism-based format | Scientific Literature | ||
2. | ALA5142717 | P | Kinetic solubility of compound incubated for 24 hrs | 59 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA5142718 | A | Metabolic stability in rat liver S9 fraction assessed as compound remaining at 3 uM measured at 60 mins by LC-MS/MS analysis | Rattus norvegicus | 35 | subcellular format | Scientific Literature | ||
4. | ALA5142720 | A | Metabolic stability in human liver S9 fraction assessed as compound remaining at 3 uM measured at 60 mins by LC-MS/MS analysis | Homo sapiens | 35 | subcellular format | Scientific Literature | ||
5. | ALA5142724 | P | Octanol/water distribution coefficient, logD of the compound at pH 7.4 sonicated for 30 mins followed by 24 hrs shaking | 53 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA5142727 | F | Antiparasitic activity against Onchocerca gutturosa assessed as reduction in motility at 1 uM | Onchocerca gutturosa | 5 | organism-based format | Scientific Literature | ||
7. | ALA5142731 | F | Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 30 mg/kg, po BID administered for 6 days | Litomosoides sigmodontis | 2 | organism-based format | Scientific Literature | ||
8. | ALA5142736 | A | Cmax in CD-1 mouse at 30 mg/kg, po measured at 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
9. | ALA5142739 | A | Tmax in CD-1 mouse at 30 mg/kg, po measured at 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
10. | ALA5142742 | A | AUC (0 to infinity) in CD-1 mouse at 30 mg/kg, po measured at 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature |