| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5130015 | B | Antagonist activity at human TLR9 expressed in HEK-blue hTLR9 cells assessed as inhibition of CpGB-induced NFkappaB activation preincubated with compound for 1 hrs followed by CpGB addition and measured next day by SEAP-based spectrophotometry assay | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
| 2. | ALA5130017 | B | Antagonist activity at human TLR7 expressed in HEK-blue hTLR7 cells assessed as inhibition of CL264-induced NFkappaB activation preincubated with compound for 1 hrs followed by CL264 addition and measured next day by SEAP-based spectrophotometry assay | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
| 3. | ALA5130023 | B | Antagonist activity at human TLR8 expressed in HEK-blue hTLR8 cells assessed as inhibition of CL075-induced NFkappaB activation at 20 uM preincubated with compound for 1 hrs followed by CL075 addition and measured next day by SEAP-based spectrophotometry assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 4. | ALA5130025 | P | Kinetic aqueous solubility of the compound in phosphate buffer at 500 uM at pH 7.4 measured after 24 hrs by HPLC-UV spectrophotometer analysis | 10 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA5130026 | A | Stability in human plasma assessed as parent compound remaining at 1 uM measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
| 6. | ALA5130027 | A | Stability in mouse plasma assessed as parent compound remaining at 1 uM measured after 2 hrs by LC-MS/MS analysis | Mus musculus | 10 | cell-free format | Scientific Literature | ||
| 7. | ALA5130028 | A | Metabolic stability in human liver microsomes assessed as half life at 5 uM measured for 60 mins by LC-MS/MS analysis | Homo sapiens | 9 | microsome format | Scientific Literature | ||
| 8. | ALA5130029 | A | Metabolic stability in mouse liver microsomes assessed as half life at 5 uM measured for 60 mins by LC-MS/MS analysis | Mus musculus | 9 | microsome format | Scientific Literature | ||
| 9. | ALA5130030 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 10. | ALA5130031 | A | Apparent permeability across basolateral to apical side in human Caco-2 cells measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 11. | ALA5130032 | A | Efflux ratio of apparent permeability across basolateral to apical side to apical to basolateral side in human Caco-2 cells measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 12. | ALA5130033 | T | Cytotoxicity against human PBMCs assessed as reduction in cell viability measured upto 20 uM after overnight incubation by PI staining based flow cytometer analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 13. | ALA5130034 | T | Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured upto 20 uM after overnight incubation by PI staining based flow cytometer analysis | Homo sapiens | 10 | cell-based format | Scientific Literature |
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