# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5139979 | Functional | Antiviral activity against HSV-2 333vhsB infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring reduction in virus-induced cytopathic effect at 50 uM incubated for 20 hrs by colorimetric analysis | Human alphaherpesvirus 2 | 44 | ALA5137030 | organism-based format | Scientific Literature | |
2. | ALA5139980 | Functional | Antiviral activity against HSV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 5 uM incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque assay | Human alphaherpesvirus 2 | 46 | ALA5137030 | organism-based format | Scientific Literature | |
3. | ALA5139981 | Functional | Antiviral activity against HSV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 1 uM incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque assay | Human alphaherpesvirus 2 | 46 | ALA5137030 | organism-based format | Scientific Literature | |
4. | ALA5139982 | Functional | Antiviral activity against HSV-1 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 5 uM incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque assay | Human alphaherpesvirus 1 | 13 | ALA5137030 | organism-based format | Scientific Literature | |
5. | ALA5139983 | Functional | Antiviral activity against HSV-1 infected in African green monkey Vero cells assessed as inhibition of viral replication by measuring log suppression of virus-induced cytopathic effect at 1 uM incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque assay | Human alphaherpesvirus 1 | 13 | ALA5137030 | organism-based format | Scientific Literature | |
6. | ALA5139985 | Functional | Antiviral activity against HSV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque reduction assay | Human alphaherpesvirus 2 | 20 | ALA5137030 | organism-based format | Scientific Literature | |
7. | ALA5139986 | Toxicity | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTS assay | Chlorocebus sabaeus | 20 | ALA5137030 | cell-based format | Scientific Literature | |
8. | ALA5139987 | Toxicity | Cytotoxicity against human HepDES19 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 19 | ALA5137030 | cell-based format | Scientific Literature | |
9. | ALA5139988 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero cells to EC50 for antiviral activity against HSV-2 infected in African green monkey Vero cells | 20 | ALA5137030 | cell-based format | Scientific Literature | ||
10. | ALA5139989 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against human HepDES19 cells to EC50 for antiviral activity against HSV-2 infected in African green monkey Vero cells | 19 | ALA5137030 | cell-based format | Scientific Literature | ||
11. | ALA5139993 | ADME | Half life in mouse liver microsomes at 2 uM in presence of NADPH by LC/MS/MS analysis | Mus musculus | 11 | ALA5137030 | microsome format | Scientific Literature | |
12. | ALA5139994 | ADME | Half life in human liver microsomes at 2 uM in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 11 | ALA5137030 | microsome format | Scientific Literature | |
13. | ALA5139995 | ADME | Apparent permeability of the compound across apical to basolateral side in human Caco-2 cells at 10 uM incubated for 2 hrs | Homo sapiens | 12 | ALA5137030 | cell-based format | Scientific Literature | |
14. | ALA5139996 | ADME | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells at 10 uM incubated for 2 hrs | Homo sapiens | 12 | ALA5137030 | cell-based format | Scientific Literature | |
15. | ALA5139997 | ADME | Half-life in BALB/c mouse at 3 mg/kg, po and 1 mg/kg, iv by LC/MS/MS analysis | Mus musculus | 5 | ALA5137030 | organism-based format | Scientific Literature | |
16. | ALA5139998 | ADME | Oral bioavailability in BALB/c mouse at 3 mg/kg by LC/MS/MS analysis | Mus musculus | 5 | ALA5137030 | organism-based format | Scientific Literature |