# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5154145 | B | Inhibition of full length human PDE9A expressed in Sf9 insect cells using [3H]-cGMP as substrate incubated for 60 mins by microbeta scintillation counter analysis | Homo sapiens | 34 | ALA5150071 | cell-based format | Scientific Literature | |
2. | ALA5154146 | B | Selectivity index, ratio of IC50 for bovine brain PDE1 to IC50 for full length human PDE9A | 16 | ALA5150071 | assay format | Scientific Literature | ||
3. | ALA5154147 | P | Solubility of compound in PBS at pH 6.5 at 50 mg/ml incubated for 24 hrs by LC/MS/MS or HPLC analysis | 3 | ALA5150071 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5154148 | B | Selectivity index, ratio of IC50 for full length human PDE2A to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
5. | ALA5154149 | B | Selectivity index, ratio of IC50 for full length human PDE3B to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
6. | ALA5154150 | B | Selectivity index, ratio of IC50 for human platelet PDE5A to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
7. | ALA5154151 | B | Selectivity index, ratio of IC50 for full length human PDE7B to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
8. | ALA5154152 | B | Selectivity index, ratio of IC50 for full length human PDE8A to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
9. | ALA5154153 | B | Selectivity index, ratio of IC50 for full length human PDE10A to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
10. | ALA5154154 | B | Selectivity index, ratio of IC50 for full length human PDE11A to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
11. | ALA5154155 | B | Selectivity index, ratio of IC50 for full length human PDE4B to IC50 for full length human PDE9A | Homo sapiens | 4 | ALA5150071 | assay format | Scientific Literature | |
12. | ALA5154156 | A | Blood clearance in po or iv dosed Wistar rat measured over 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5150071 | organism-based format | Scientific Literature | |
13. | ALA5154157 | A | MRT in iv dosed Wistar rat measured over 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5150071 | organism-based format | Scientific Literature | |
14. | ALA5154158 | A | Oral bioavailability in Wistar rat measured over 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA5150071 | organism-based format | Scientific Literature | |
15. | ALA5154176 | B | Inhibition of full length human PDE2A using [3H]-cGMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis | Homo sapiens | 1 | ALA5150071 | single protein format | Scientific Literature | |
16. | ALA5154177 | B | Inhibition of human platelet PDE5A using [3H]-cGMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis | Homo sapiens | 1 | ALA5150071 | cell-based format | Scientific Literature | |
17. | ALA5154178 | B | Inhibition of full length human PDE7B using [3H]-cAMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis | Homo sapiens | 1 | ALA5150071 | single protein format | Scientific Literature | |
18. | ALA5154179 | B | Inhibition of full length human PDE8A using [3H]-cAMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis | Homo sapiens | 1 | ALA5150071 | single protein format | Scientific Literature | |
19. | ALA5154180 | B | Inhibition of full length human PDE10A using [3H]-cAMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis | Homo sapiens | 1 | ALA5150071 | single protein format | Scientific Literature | |
20. | ALA5154181 | B | Inhibition of full length human PDE11A using [3H]-cAMP as substrate at <5 uM incubated for 60 mins by microbeta scintillation counter analysis | Homo sapiens | 1 | ALA5150071 | single protein format | Scientific Literature |