# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5168101 | Functional | Antiproliferative activity against human SNU-16 cells expressing FGFR2 assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5154932 | cell-based format | Scientific Literature | |
2. | ALA5168102 | Functional | Antiproliferative activity against human RT-112 cells expressing FGFR3 assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5154932 | cell-based format | Scientific Literature | |
3. | ALA5168103 | Binding | Inhibition of wild type FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA | Homo sapiens | 36 | ALA5154932 | single protein format | Scientific Literature | |
4. | ALA5168104 | Binding | Inhibition of FGFR4 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA | Homo sapiens | 36 | ALA5154932 | single protein format | Scientific Literature | |
5. | ALA5168105 | Functional | Antiproliferative activity against human Hep3B cells expressing FGF19/FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Homo sapiens | 31 | ALA5154932 | cell-based format | Scientific Literature | |
6. | ALA5168106 | Functional | Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Homo sapiens | 30 | ALA5154932 | cell-based format | Scientific Literature | |
7. | ALA5168107 | Binding | Selectivity ratio of IC50 for FGFR1 (unknown origin) to IC50 for FGFR4 (unknown origin) | Homo sapiens | 30 | ALA5154932 | assay format | Scientific Literature | |
8. | ALA5168108 | Binding | Inhibition of wild type FGFR2 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA | Homo sapiens | 2 | ALA5154932 | single protein format | Scientific Literature | |
9. | ALA5168109 | Binding | Inhibition of wild type FGFR3 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA | Homo sapiens | 2 | ALA5154932 | single protein format | Scientific Literature | |
10. | ALA5168110 | Binding | Inhibition of FGFR4 V550L mutant (unknown origin) at 1 uM using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA | Homo sapiens | 2 | ALA5154932 | single protein format | Scientific Literature | |
11. | ALA5168111 | Functional | Antiproliferative activity against human NCI-H1581 cells expressing FGFR1 assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 3 | ALA5154932 | cell-based format | Scientific Literature | |
12. | ALA5168112 | Functional | Antiproliferative activity against mouse BaF3 cells expressing TEL-FGFR4 assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Mus musculus | 3 | ALA5154932 | cell-based format | Scientific Literature | |
13. | ALA5168113 | Binding | Inhibition of FGFR4 signalling pathway in human Hep3B cells assessed as inhibition of FGFR4 phosphorylation incubated for 24 hrs followed by seeding measured after 48 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5154932 | cell-based format | Scientific Literature | |
14. | ALA5168114 | Binding | Inhibition of FGFR4 signalling pathway in human Hep3B cells assessed as inhibition of PLC gamma phosphorylation incubated for 24 hrs followed by seeding measured after 48 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5154932 | cell-based format | Scientific Literature | |
15. | ALA5168115 | Binding | Inhibition of FGFR4 signalling pathway in human Hep3B cells assessed as inhibition of ERK phosphorylation incubated for 24 hrs followed by seeding measured after 48 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5154932 | cell-based format | Scientific Literature | |
16. | ALA5168116 | Functional | Induction of cell cycle arrest in human Hep3B cells assessed as increase in DNA content at G1/M phase at 50 nM incubated for 48 hrs by propidium iodide/RNAse staining based flow cytometry analysis | Homo sapiens | 2 | ALA5154932 | cell-based format | Scientific Literature | |
17. | ALA5168117 | Functional | Induction of cell cycle arrest in human Hep3B cells assessed as increase in DNA content at G1/M phase at 100 nM incubated for 48 hrs by propidium iodide/RNAse staining based flow cytometry analysis | Homo sapiens | 2 | ALA5154932 | cell-based format | Scientific Literature | |
18. | ALA5168118 | Functional | Induction of apoptosis in human Hep3B cells assessed as viable cells at 1 uM incubated for 48 hrs by annexin V-FITC and PI staining based flow cytometry (Rvb = 87.7%) | Homo sapiens | 2 | ALA5154932 | cell-based format | Scientific Literature | |
19. | ALA5168119 | Functional | Induction of apoptosis in human Hep3B cells assessed as early apoptotic cells at 1 uM incubated for 48 hrs by annexin V-FITC and PI staining based flow cytometry (Rvb = 2.23%) | Homo sapiens | 2 | ALA5154932 | cell-based format | Scientific Literature | |
20. | ALA5168120 | Functional | Induction of apoptosis in human Hep3B cells assessed as late apoptotic cells at 1 uM incubated for 48 hrs by annexin V-FITC and PI staining based flow cytometry (Rvb = 2.53%) | Homo sapiens | 2 | ALA5154932 | cell-based format | Scientific Literature |