# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5130499 | B | Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assay | Homo sapiens | 17 | ALA5126625 | single protein format | Scientific Literature | |
2. | ALA5130501 | B | Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assay | Homo sapiens | 17 | ALA5126625 | cell-based format | Scientific Literature | |
3. | ALA5130502 | B | Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by chemiluminescence assay | Homo sapiens | 17 | ALA5126625 | cell-based format | Scientific Literature | |
4. | ALA5130503 | B | Selectivity ratio of IC50 for human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells to IC50 for MPO in human HL-60 cells | Homo sapiens | 17 | ALA5126625 | cell-based format | Scientific Literature | |
5. | ALA5130504 | B | Irreversible inhibition of MPO (unknown origin) assessed as fold shift in EC50 incubated with compound followed by drug washing and later treated with H2O2 for enzyme reactivation by chemiluminescence assay | Homo sapiens | 17 | ALA5126625 | single protein format | Scientific Literature | |
6. | ALA5130508 | P | Lipophilicity, log D of the compound | 14 | ALA5126625 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5130509 | P | Thermodynamic solubility of the compound in phosphate buffer at pH 7.4 incubated for 18 hrs by shake flask method | 14 | ALA5126625 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5130510 | A | Intrinsic clearance in human liver microsomes at 1 uM measured up to 30 mins in presence of NADPH measured per mg protein by LC-MS/MS analysis | Homo sapiens | 14 | ALA5126625 | microsome format | Scientific Literature | |
9. | ALA5130511 | A | Intrinsic clearance in Wistar Han rat hepatocytes at 1 uM measured up to 120 mins measured per 10^6 cells by LC-MS/MS analysis | Rattus norvegicus | 14 | ALA5126625 | cell-based format | Scientific Literature | |
10. | ALA5130512 | A | Intrinsic clearance in human hepatocytes at 1 uM measured up to 120 mins measured per 10^6 cells by LC-MS/MS analysis | Homo sapiens | 14 | ALA5126625 | cell-based format | Scientific Literature | |
11. | ALA5130513 | A | Apparent permeability of the compound across apical to basolateral side in human Caco-2 cells at 10 uM by LC-MS/MS analysis | Homo sapiens | 14 | ALA5126625 | cell-based format | Scientific Literature |