| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5148412 | F | Agonist activity at human APJ receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by TR-FRET based LANCE cAMP assay | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
| 2. | ALA5148413 | F | Agonist activity at human APJ receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by measuring maximal efficacy after 30 mins by TR-FRET based LANCE cAMP assay relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 3. | ALA5148414 | F | Agonist activity at human APJ receptor expressed in CHO cells co-expressing Galphaq16 assessed as stimulation of Ca2+ mobilization measured at 1 sec interval for 90 sec by fluorescent Calcium 5-dye based FLIPR-calcium mobilization assay | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
| 4. | ALA5148415 | F | Agonist activity at human APJ receptor expressed in CHO cells co-expressing Galphaq16 assessed as stimulation of Ca2+ mobilization by measuring maximal efficacy at 1 sec interval for 90 sec by fluorescent Calcium 5-dye based FLIPR-calcium mobilization assay relative to control | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 5. | ALA5148416 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 1 uM measured after 30 mins in the presence of NADPH by LC-MS analysis | Rattus norvegicus | 46 | microsome format | Scientific Literature | ||
| 6. | ALA5148417 | A | Apparent permeability from apical to basolateral side in human Caco-2 cells by LC-MS/MS analysis | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 7. | ALA5148418 | A | Apparent permeability from basolateral to apical side in human Caco-2 cells by LC-MS/MS analysis | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 8. | ALA5148419 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in human Caco-2 cells by LC-MS/MS analysis | Homo sapiens | 21 | cell-based format | Scientific Literature |
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