| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5164092 | F | Antagonist activity at human M2 receptor at 10 uM relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA5164093 | A | Ratio of drug concentration in brain to plasma of Sprague-Dawley rat at 3 mg/kg, iv measured up to 480 mins by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA5164094 | B | Displacement of [3H]-LSD from human 5-HT6R stably expressed in HEK293 cells by radioligand binding assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA5164095 | B | Inhibition of human recombinant MAO-B using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by fluorometric analysis | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 5. | ALA5164097 | T | Inhibition of human recombinant ERG at 1 uM in presence of dofetilide relative to control | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 6. | ALA5164098 | B | Inhibition of human recombinant MAO-A using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by fluorometric analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA5164099 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 30 to 60 mins by UPLC/MS analysis | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
| 8. | ALA5164100 | B | Reversible inhibition of human recombinant MAO-B assessed as increase in enzymatic activity using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured every 5 mins for 5 hrs by fluorescence based assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 9. | ALA5164101 | B | Reversible inhibition of human recombinant MAO-B using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured every 5 mins by fluorescence based assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA5164102 | B | Mixed mode inhibition of human recombinant MAO-B using p-tyramine as substrate with varying concentration preincubated for 30 mins followed by substrate addition and measured every 5 mins for 5 hrs by Lineweaver-burk plot analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA5164103 | A | Inhibition of CYP2C9 (unknown origin) using sulfaphenazole as substrate by luminescence method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA5164104 | A | Inhibition of CYP3A4 (unknown origin) using ketoconazole as substrate by luminescence method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA5164105 | A | Inhibition of CYP2D6 (unknown origin) using quinidine as substrate by luminescence method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA5164106 | T | Hepatotoxicity in human HepG2 cells at 0.1 to 100 uM incubated for 24 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5164107 | T | Cytotoxicity against mouse C8D1A astrocyte cells assessed as mitochondrial metabolism in C8-D1A astrocytes at up to 5 uM by MTT assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5164108 | T | Mutagenicity in Salmonella typhimurium TA100 at 1 to 10 uM incubated for 72 hrs by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | assay format | Scientific Literature | ||
| 17. | ALA5164109 | F | Cytoprotective activity against DOX-induced mouse C8D1A astrocyte death at 0.25 uM incubated for 24 hrs by MTT assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5164110 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg measured up to 480 mins by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5164111 | A | Bioavailability in Sprague-Dawley rat at 3 mg/kg, iv measured up to 480 mins by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5164112 | A | Cmax in Sprague-Dawley rat brain at 3 mg/kg, po measured after 2 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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