# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5106642 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as bacterial growth inhibition incubated for 5 days under normoxic condition by resazurin microtiter assay | Mycobacterium tuberculosis | 19 | ALA5104178 | organism-based format | Scientific Literature | |
2. | ALA5106648 | Binding | Substrate activity at Mycobacterium tuberculosis Ddn expressed in Escherichia coli BL21 (DE3) assessed as oxidation of F420H2 by measuring Kcat by spectrophotometric analysis | Mycobacterium tuberculosis | 15 | ALA5104178 | assay format | Scientific Literature | |
3. | ALA5106649 | Binding | Substrate activity at Mycobacterium tuberculosis Ddn expressed in Escherichia coli BL21 (DE3) assessed as oxidation of F420H2 by measuring Km by spectrophotometric analysis | Mycobacterium tuberculosis | 15 | ALA5104178 | assay format | Scientific Literature | |
4. | ALA5106650 | Binding | Substrate activity at Mycobacterium tuberculosis Ddn expressed in Escherichia coli BL21 (DE3) assessed as oxidation of F420H2 by measuring Kcat/Km by spectrophotometric analysis | Mycobacterium tuberculosis | 15 | ALA5104178 | assay format | Scientific Literature | |
5. | ALA5106652 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as bacterial growth inhibition at 32 ug/ml incubated for 5 days under hypoxic condition by resazurin microtiter assay relative to control | Mycobacterium tuberculosis | 1 | ALA5104178 | organism-based format | Scientific Literature | |
6. | ALA5231915 | Physicochemical | Water solubility of compound at pH 7.4 measured after 24 hrs by LC-UV analysis | 43 | ALA5230134 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5231916 | Physicochemical | Solubility of the compound at pH 7.4 in PBS measured after 24 hrs by LC-UV analysis | 43 | ALA5230134 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5231917 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv measured for 48 hrs under normoxia condition by resazurin dye based microplate reader analysis | Mycobacterium tuberculosis | 44 | ALA5230134 | organism-based format | Scientific Literature | |
9. | ALA5231919 | Functional | Antiparasitic activity against Trypanosoma brucei brucei BS427 assessed as parasite growth inhibition measured after 48 hrs by resazurin dye based assay | Trypanosoma brucei brucei | 39 | ALA5230134 | organism-based format | Scientific Literature | |
10. | ALA5231920 | Functional | Antitrypanosomal activity against Trypanosoma cruzi ATCC CCL92 assessed as reduction in viable parasite measured after 48 hrs by Hoechst 33342 staining based microscopic analysis | Trypanosoma cruzi | 42 | ALA5230134 | organism-based format | Scientific Literature | |
11. | ALA5231921 | Toxicity | Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 20 hrs | Homo sapiens | 43 | ALA5230134 | cell-based format | Scientific Literature | |
12. | ALA5231922 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 32 microg/ml measured for 48 hrs under hypoxia condition by resazurin dye based microplate reader analysis relative to control | Mycobacterium tuberculosis | 4 | ALA5230134 | organism-based format | Scientific Literature | |
13. | ALA5231927 | Physicochemical | Solubility of the compound at pH 4.5 in acetate buffer measured after 24 hrs by LC-UV analysis | 27 | ALA5230134 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA5231928 | Physicochemical | Solubility of the compound at pH 1 in HCL measured after 24 hrs by LC-UV analysis | 27 | ALA5230134 | small-molecule physicochemical format | Scientific Literature |