# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5158614 | B | Inhibition of full-length ovine COX-1 at 5 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control | Ovis aries | 24 | single protein format | Scientific Literature | ||
2. | ALA5158615 | B | Inhibition of full-length ovine COX-1 at 50 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control | Ovis aries | 24 | single protein format | Scientific Literature | ||
3. | ALA5158616 | B | Inhibition of human COX-2 at 5 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control | Homo sapiens | 24 | single protein format | Scientific Literature | ||
4. | ALA5158617 | B | Inhibition of human COX-2 at 50 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control | Homo sapiens | 24 | single protein format | Scientific Literature | ||
5. | ALA5158618 | B | Inhibition of full-length ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry | Ovis aries | 10 | single protein format | Scientific Literature | ||
6. | ALA5158619 | B | Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry | Homo sapiens | 10 | single protein format | Scientific Literature | ||
7. | ALA5158620 | B | Selectivity index, ratio of IC50 for human COX-2 to IC50 for full-length ovine COX-1 | 9 | assay format | Scientific Literature | |||
8. | ALA5158621 | B | Inhibition of COX in human HeLa cells assessed as reduction in PGE2 level at 50 uM measured after 24 hrs by ELISA relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
9. | ALA5158622 | B | Inhibition of COX in human HeLa cells assessed as reduction in PGE2 level at 100 uM measured after 24 hrs by ELISA relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
10. | ALA5158623 | F | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
11. | ALA5158629 | F | Cytotoxicity against human LNCaP cells over expressing androgen receptor F876L mutant assessed as reduction in cell viability measured after 72 hrs by MTS assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
12. | ALA5158630 | F | Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTS assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
13. | ALA5158632 | F | Cytotoxicity against human A549 cells assessed as reduction in cell viability at 2.5 to 500 uM measured after 72 hrs by MTS assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
14. | ALA5158633 | T | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability at 2.5 to 500 uM measured after 72 hrs by MTS assay | Chlorocebus sabaeus | 8 | cell-based format | Scientific Literature | ||
15. | ALA5158634 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 2.5 to 500 uM measured after 72 hrs by MTS assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
16. | ALA5158635 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 2.5 to 500 uM measured after 72 hrs by MTS assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
17. | ALA5158636 | F | Cytotoxicity against human DU-145 cells assessed as reduction in cell viability at 2.5 to 500 uM measured after 72 hrs by MTS assay | Homo sapiens | 4 | cell-based format | Scientific Literature |