# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5155932 | B | Inhibition of Tag2-PD-1/Tag1-PD-L1 (unknown origin) protein-protein interaction incubated for 15 mins by HTRF assay | Homo sapiens | 23 | ALA5154658 | protein complex format | Scientific Literature | |
2. | ALA5155933 | B | Binding affinity to human PD-L1 assessed as change in melting temperature at 10 uM by thermal shift based DSF assay | Homo sapiens | 1 | ALA5154658 | single protein format | Scientific Literature | |
3. | ALA5155934 | B | Binding affinity to human PD-L1 assessed as change in melting temperature at 20 uM by thermal shift based DSF assay | Homo sapiens | 1 | ALA5154658 | single protein format | Scientific Literature | |
4. | ALA5155935 | B | Binding affinity to human PD-L1 assessed as change in melting temperature at 50 uM by thermal shift based DSF assay | Homo sapiens | 1 | ALA5154658 | single protein format | Scientific Literature | |
5. | ALA5155936 | B | Inhibition of PD-1/PD-L1 interaction in CHO cells expressing PD-Ll/TCR cocultured with human Jurkat cells expressing PD-1 assessed as T-cell activation by measuring maximum relative luminescence intensity value at 10 uM incubated for 6 hrs by luciferase reporter gene assay | Homo sapiens | 2 | ALA5154658 | cell-based format | Scientific Literature | |
6. | ALA5155937 | T | Cytotoxicity against human PBMC cells assessed as reduction in cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA5154658 | cell-based format | Scientific Literature | |
7. | ALA5155938 | B | Inhibition of PD-1/PD-L1 interaction in human CD3+ T-cells co-cultured with Hep3B cells expressing OS8/hPD-L1 assessed as increase in IFN-gamma secretion measured after 72 hrs by ELISA | Homo sapiens | 2 | ALA5154658 | assay format | Scientific Literature | |
8. | ALA5155939 | B | Inhibition of PD-1/PD-L1 interaction in human CD3+ T-cells co-cultured with Hep3B cells expressing OS8/hPD-L1 assessed as increase in IFN-gamma secretion at 2.22 uM measured after 72 hrs by ELISA | Homo sapiens | 2 | ALA5154658 | assay format | Scientific Literature | |
9. | ALA5155940 | B | Binding affinity to human PD-1 assessed as change in melting temperature at 10 to 50 uM by thermal shift based DSF assay | Homo sapiens | 1 | ALA5154658 | single protein format | Scientific Literature | |
10. | ALA5155941 | T | Cytotoxicity against human PBMC cells assessed as reduction in cell growth at 0.003 to 2.22 uM incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA5154658 | cell-based format | Scientific Literature | |
11. | ALA5155942 | T | Cytotoxicity against human PBMC cells assessed as reduction in cell growth at >2.22 uM incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA5154658 | cell-based format | Scientific Literature |