# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5120395 | P | Chemical stability in PBS buffer assessed hydrolysis by measuring formation of diphosphate derivative measured after 58 hrs by RP-HPLC analysis relative to control | 2 | ALA5113536 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA5120396 | P | Chemical stability in PBS buffer assessed reduction in hydrolysis measured after 24 hrs in presence of CEM/0 cell extract medium by RP-HPLC analysis relative to control | 2 | ALA5113536 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5120400 | A | Metabolic stability of the compound in mouse liver extract assessed as compound remaining measured after 24 hrs in presence of mouse liver extract medium by RP-HPLC analysis relative to control | Mus musculus | 1 | ALA5113536 | tissue-based format | Scientific Literature | |
4. | ALA5120403 | F | Antiviral activity against HIV1 HE strain infected in CEM/0 cells assessed as inhibition of HIV induced cytopathogenic effects | Human immunodeficiency virus 1 | 5 | ALA5113536 | organism-based format | Scientific Literature | |
5. | ALA5120404 | F | Antiviral activity against HIV2 ROD infected in CEM/0 cells assessed as inhibition of HIV induced cytopathogenic effects | Human immunodeficiency virus 2 | 5 | ALA5113536 | organism-based format | Scientific Literature | |
6. | ALA5120405 | F | Antiviral activity against thymidine deficient HIV2 ROD infected in CEM-TK(-) cells assessed as inhibition of HIV induced cytopathogenic effects | Human immunodeficiency virus 2 | 5 | ALA5113536 | organism-based format | Scientific Literature | |
7. | ALA5120406 | T | Cytotoxicity in human CEM/0 cells assessed as reduction in cell viability | Homo sapiens | 5 | ALA5113536 | cell-based format | Scientific Literature | |
8. | ALA5120407 | B | Substrate activity at HIV reverse transcriptase assessed as DNA elongation using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 15 mins and at 80 degreeC for 3 mins by primer extension assay | Human immunodeficiency virus | 2 | ALA5113536 | assay format | Scientific Literature | |
9. | ALA5120408 | B | Substrate activity at human DNA polymerase beta using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 60 mins and at 80 degreeC for 3 mins by primer extension assay | Homo sapiens | 2 | ALA5113536 | single protein format | Scientific Literature | |
10. | ALA5120409 | B | Substrate activity at human DNA polymerase alpha using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 60 mins and at 80 degreeC for 3 mins by primer extension assay | Homo sapiens | 2 | ALA5113536 | single protein format | Scientific Literature | |
11. | ALA5120410 | B | Substrate activity at human DNA polymerase gamma using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 60 mins and at 80 degreeC for 3 mins by primer extension assay | Homo sapiens | 2 | ALA5113536 | assay format | Scientific Literature | |
12. | ALA5120412 | B | Substrate activity at HIV reverse transcriptase assessed as DNA elongation using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 15 mins and at 80 degreeC for 3 mins in presence of TTP by primer extension assay | Human immunodeficiency virus | 2 | ALA5113536 | assay format | Scientific Literature | |
13. | ALA5120413 | P | Chemical stability in PBS buffer assessed hydrolysis by measuring formation of monophosphate derivative measured after 58 hrs by RP-HPLC analysis relative to control | 2 | ALA5113536 | small-molecule physicochemical format | Scientific Literature |