| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5167089 | F | Inhibition of cell proliferation in human MDA-MB-453 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay | Homo sapiens | 22 | ALA5154909 | cell-based format | Scientific Literature | |
| 2. | ALA5167092 | B | Inhibition of N-terminal GST tagged FGFR4 (unknown origin) expressed in baculovirus infected sf21 insect cells incubated for 2 hrs by HTRF analysis | Homo sapiens | 23 | ALA5154909 | cell-based format | Scientific Literature | |
| 3. | ALA5167093 | F | Inhibition of cell proliferation in human Huh-7 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay | Homo sapiens | 22 | ALA5154909 | cell-based format | Scientific Literature | |
| 4. | ALA5167094 | B | Time-dependent inhibition of FGFR4 (unknown origin) at 4 nM preincubated for 45 mins followed by substrate and ATP addition by HTRF analysis | Homo sapiens | 2 | ALA5154909 | single protein format | Scientific Literature | |
| 5. | ALA5167097 | B | Inhibition of BODIPY-FL-labeled 3-(3-(4-(3-acrylamido-4-((3-(3,5-dimethoxybenzoyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)amino)phenyl)piperazin-1-yl)-3-oxopropyl)-5,5-difluoro-7,9-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide probe binding to recombinant FGFR4 (unknown origin) preincubated for 2 hrs followed by probe treatment for 2 hrs by SDS/PAGE and fluorescent gel scanning analysis | Homo sapiens | 4 | ALA5154909 | single protein format | Scientific Literature | |
| 6. | ALA5167098 | B | Inhibition of FGFR4 (unknown origin) at 1 uM by Z'-LYTE assay relative to control | Homo sapiens | 2 | ALA5154909 | single protein format | Scientific Literature | |
| 7. | ALA5167102 | B | Inhibition of FGFR1 (unknown origin) at upto 10 uM by Z'-LYTE assay | Homo sapiens | 1 | ALA5154909 | single protein format | Scientific Literature | |
| 8. | ALA5167103 | B | Inhibition of FGFR2 (unknown origin) at upto 10 uM by Z'-LYTE assay | Homo sapiens | 1 | ALA5154909 | single protein format | Scientific Literature | |
| 9. | ALA5167104 | B | Inhibition of TTK (unknown origin) at upto 10 uM by Lantha screen assay | Homo sapiens | 1 | ALA5154909 | single protein format | Scientific Literature | |
| 10. | ALA5167106 | B | Inhibition of FGF19 induced FGFR4 signalling in human Huh-7 cells assessed as inhibition of FRS2alpha phosphorylation at Y436 residue at 10 nM incubated for 1 hr followed by FGF19 stimulation for 10 mins by Western blot analysis | Homo sapiens | 1 | ALA5154909 | cell-based format | Scientific Literature | |
| 11. | ALA5167107 | B | Inhibition of FGF19 induced FGFR4 signalling in human Huh-7 cells assessed as inhibition of AKT phosphorylation at S473 residue incubated for 1 hr followed by FGF19 stimulation for 10 mins by Western blot analysis | Homo sapiens | 2 | ALA5154909 | cell-based format | Scientific Literature | |
| 12. | ALA5167108 | B | Inhibition of FGF19 induced FGFR4 signalling in human Huh-7 cells assessed as inhibition of ERK phosphorylation at T202/Y204 residues incubated for 1 hr followed by FGF19 stimulation for 10 mins by Western blot analysis | Homo sapiens | 2 | ALA5154909 | cell-based format | Scientific Literature | |
| 13. | ALA5167109 | B | Irreversible inhibition of FGFR4 signalling in human Huh-7 cells assessed as inhibition of ERK1/2 phosphorylation at 30 nM preincubated for 1 hr followed by compound washout with PBS and stimulated with FGF19 for 10 mins by Western blot analysis | Homo sapiens | 1 | ALA5154909 | cell-based format | Scientific Literature | |
| 14. | ALA5167111 | A | AUC (0 to t) in BALB/c mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154909 | organism-based format | Scientific Literature | |
| 15. | ALA5167112 | A | AUC (0 to t) in BALB/c mouse at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154909 | organism-based format | Scientific Literature | |
| 16. | ALA5167113 | A | AUC (0 to infinity) in BALB/c mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154909 | organism-based format | Scientific Literature | |
| 17. | ALA5167114 | A | AUC (0 to infinity) in BALB/c mouse at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154909 | organism-based format | Scientific Literature | |
| 18. | ALA5167115 | A | Half life in BALB/c mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154909 | organism-based format | Scientific Literature | |
| 19. | ALA5167116 | A | Half life in BALB/c mouse at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154909 | organism-based format | Scientific Literature | |
| 20. | ALA5167117 | A | Apparent volume of distribution in BALB/c mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5154909 | organism-based format | Scientific Literature |
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