# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5159130 | B | Inhibition of recombinant human GST-Xa-tagged-AAK1 (30 to 330 residues) using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 as substrate incubated for 3 hrs in presence of ATP by electrophoretic analysis | Homo sapiens | 31 | single protein format | Scientific Literature | ||
2. | ALA5159132 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
3. | ALA5159133 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
4. | ALA5159134 | B | Inhibition of full length human AAK1 expressed in HEK293F incubated for 3 hrs by Western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
5. | ALA5159135 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
6. | ALA5159136 | A | Plasma protein binding in human assessed as unbound fraction at 10 uM incubated for 5 hrs by rapid equlibrium dialysis based LC-MS/MS method | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
7. | ALA5159137 | A | Plasma protein binding in rat assessed as unbound fraction at 10 uM incubated for 5 hrs by rapid equlibrium dialysis based LC-MS/MS method | Rattus norvegicus | 6 | cell-free format | Scientific Literature | ||
8. | ALA5159138 | A | Plasma protein binding in mouse assessed as unbound fraction at 10 uM incubated for 5 hrs by rapid equlibrium dialysis based LC-MS/MS method | Mus musculus | 6 | cell-free format | Scientific Literature | ||
9. | ALA5159139 | A | Permeability of the compound at pH 7.4 by PAMPA | 6 | assay format | Scientific Literature | |||
10. | ALA5159140 | A | Permeability of the compound at pH 5.5 by PAMPA | 6 | assay format | Scientific Literature | |||
11. | ALA5159141 | A | Permeability across apical to basolateral side in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
12. | ALA5159142 | A | Permeability across basolateral to apical side in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 6 | cell-based format | Scientific Literature |