# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5154106 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial cell growth by measuring resazurin reduction incubated for 6 days by fluorescence microplate based assay | Mycobacterium tuberculosis | 12 | ALA5150070 | organism-based format | Scientific Literature | |
2. | ALA5154107 | Binding | Inhibition of Mycobacterium tuberculosis recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation in the presence of an electron acceptor menadione | Mycobacterium tuberculosis | 7 | ALA5150070 | assay format | Scientific Literature | |
3. | ALA5154108 | Binding | Inhibition of Mycobacterium smegmatis MC2 155 recombinant type II NADH dehydrogenase ndh expressed in Escherichia coli assessed as rate of NADH oxidation in the presence of an electron acceptor menadione | Mycolicibacterium smegmatis | 7 | ALA5150070 | assay format | Scientific Literature | |
4. | ALA5154109 | Binding | Inhibition of Mycobacterium smegmatis MC2 155 recombinant ndhA assessed as rate of NADH oxidation in the presence of an electron acceptor menadione | Mycolicibacterium smegmatis | 7 | ALA5150070 | single protein format | Scientific Literature | |
5. | ALA5154110 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in human A-THP1 macrophages assessed as viability of infected macrophages incubated for 96 hrs by fluorescence microplate assay | Mycobacterium tuberculosis | 10 | ALA5150070 | organism-based format | Scientific Literature | |
6. | ALA5154111 | Physicochemical | Octanol/PBS partition coefficient, logD of compound at pH 7.4 measured after 2 hrs by shake flask method | 7 | ALA5150070 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5154137 | Functional | in vivo antimycobacterial efficacy in Mycobacterium marinum infected zebrafish larvae assessed as reduction in bacterial burden at 0.25 to 2 micog/ml measured after 2 to 4 days off post infection | Mycobacterium tuberculosis | 3 | ALA5150070 | organism-based format | Scientific Literature | |
8. | ALA5154138 | Toxicity | Toxicity in noninfected zebrafish larvae assessed as larval development | Danio rerio | 3 | ALA5150070 | assay format | Scientific Literature | |
9. | ALA5154139 | Toxicity | Toxicity in noninfected zebrafish larvae assessed as toxic effect | Danio rerio | 3 | ALA5150070 | assay format | Scientific Literature | |
10. | ALA5154140 | Functional | In vivo antimycobacterial efficacy in Mycobacterium marinum expressing Wasabi infected zebrafish larvae assessed as prolongation of survival treated for 4 days after 1 day post infection | Mycobacterium marinum | 3 | ALA5150070 | organism-based format | Scientific Literature | |
11. | ALA5154141 | Functional | In vivo antimycobacterial efficacy in Mycobacterium marinum expressing Wasabi infected zebrafish larvae assessed as prolongation of survival time at 4.8 uM treated for 4 days after 1 day post infection | Mycobacterium marinum | 3 | ALA5150070 | organism-based format | Scientific Literature |