# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5167243 | ADME | Oral bioavailability in BALB/c mouse infected with Influenza A A/WSN/33 (H1N1) virus at 50 mg/kg measured after 24 hrs by LC-MS analysis | Mus musculus | 1 | ALA5154914 | organism-based format | Scientific Literature | |
2. | ALA5167244 | ADME | Tmax in BALB/c mouse infected with Influenza A A/WSN/33 (H1N1) virus at 50 mg/kg, po administered as single dose measured after 24 hrs by LC-MS analysis | Mus musculus | 1 | ALA5154914 | organism-based format | Scientific Literature | |
3. | ALA5167245 | ADME | Elimination half life in BALB/c mouse infected with Influenza A A/WSN/33 (H1N1) virus at 50 mg/kg, po measured after 24 hrs by LC-MS analysis | Mus musculus | 1 | ALA5154914 | organism-based format | Scientific Literature | |
4. | ALA5167246 | ADME | Elimination half life in BALB/c mouse infected with Influenza A A/WSN/33 (H1N1) virus at 10 mg/kg, iv measured after 24 hrs by LC-MS analysis | Mus musculus | 1 | ALA5154914 | organism-based format | Scientific Literature | |
5. | ALA5167248 | Binding | Binding affinity to human recombinant VHL assessed as dissociation constant by SPR assay | Homo sapiens | 3 | ALA5154914 | single protein format | Scientific Literature | |
6. | ALA5167249 | Binding | Binding affinity to recombinant influenza A hemagglutinin assessed as dissociation constant by SPR assay | Influenza A virus | 3 | ALA5154914 | single protein format | Scientific Literature | |
7. | ALA5167250 | ADME | AUCinfinity in BALB/c mouse infected with Influenza A A/WSN/33 (H1N1) virus at 10 mg/kg, iv measured after 24 hrs by LC-MS analysis | Mus musculus | 1 | ALA5154914 | organism-based format | Scientific Literature | |
8. | ALA5167253 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as degradation of hemagglutinin incubated for 24 hrs by Western blot analysis | 3 | ALA5154914 | cell-based format | Scientific Literature | ||
9. | ALA5167254 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as degradation of hemagglutinin at 33 uM incubated for 24 hrs by Western blot analysis relative to control | 3 | ALA5154914 | cell-based format | Scientific Literature | ||
10. | ALA5167255 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as degradation of hemagglutinin incubated for 10 hrs by Western blot analysis | 2 | ALA5154914 | cell-based format | Scientific Literature | ||
11. | ALA5167257 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as degradation of hemagglutinin incubated for 12 hrs by Western blot analysis | 3 | ALA5154914 | cell-based format | Scientific Literature | ||
12. | ALA5167258 | Toxicity | Cytotoxicity against HEK293T cells assessed as reduction in cell viability at 50 uM incubated for 36 hrs by Celltiter-Glo assay | Homo sapiens | 4 | ALA5154914 | cell-based format | Scientific Literature | |
13. | ALA5167259 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as degradation of hemagglutinin incubated for 7 to 10 hrs by Western blot analysis | 1 | ALA5154914 | cell-based format | Scientific Literature | ||
14. | ALA5167261 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as degradation of hemagglutinin at 25 uM preincubated with proteosome inhibitor, MG-132 at 30 uM for 2 hrs followed by compound addition by immunoblotting analysis | 1 | ALA5154914 | cell-based format | Scientific Literature | ||
15. | ALA5167262 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as accumulation of ubiquitinated hemagglutinin at 20 uM preincubated for 4 hrs followed by proteosome inhibitor, MG-132 addition and measured after 4 hrs by Immunoprecipitation analysis | 1 | ALA5154914 | cell-based format | Scientific Literature | ||
16. | ALA5167264 | Binding | Protac activity at VHL (unknown origin)/influenza A hemagglutinin transfected in HEK293T cells assessed as reduction in hemagglutinin level at 10 uM by immunoblotting analysis relative to control | 1 | ALA5154914 | cell-based format | Scientific Literature | ||
17. | ALA5167265 | Binding | Induction of degradation of influenza A Hemagglutinin transfected in HEK293T cells with siRNA-mediated VHL knockdown assessed as reduction in hemagglutinin level at upto 20 uM by immunoblotting analysis | Influenza A virus | 1 | ALA5154914 | cell-based format | Scientific Literature | |
18. | ALA5167266 | Functional | Antiviral activity against influenza A A/WSN/33 (H1N1) infected in HEK293T cells assessed as reduction in viral entry at early stage at 25 uM mesured after 3 to 9 hrs by immunofluorescence based confocal microscopic analysis | Influenza A virus | 1 | ALA5154914 | organism-based format | Scientific Literature | |
19. | ALA5167267 | Functional | Antiviral activity against pseudo typed Influenza A A/WSN/33 (H1N1) virus infected in HEK293T cells assessed as inhibition of viral entry at 10 uM measured after 72 hrs by bright Glo-luciferase reporter gene assay | Influenza A virus | 1 | ALA5154914 | organism-based format | Scientific Literature | |
20. | ALA5167268 | Binding | Inhibition of Influenza A A/WSN/33 (H1N1) virus hemagglutinin in chicken RBC assessed as inhibition of HA-mediated hemagglutination at 0.75 to 25 uM incubated for 30 min | Influenza A virus | 1 | ALA5154914 | cell-based format | Scientific Literature |