# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5155946 | ADME | Oral bioavailability in Wistar rat at 3 mg/kg | Rattus norvegicus | 1 | ALA5154659 | organism-based format | Scientific Literature | |
2. | ALA5155947 | Physicochemical | Aqueous solubility of compound at pH 7.4 | 3 | ALA5154659 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5155949 | Toxicity | Inhibition of human ERG | Homo sapiens | 3 | ALA5154659 | assay format | Scientific Literature | |
4. | ALA5155950 | ADME | Half life in Wistar rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA5154659 | organism-based format | Scientific Literature | |
5. | ALA5155951 | Binding | Binding affinity to human adenosine A1A receptor expressed in human HEK293 cell membrane at 10 uM by radioligand inhibition assay | Homo sapiens | 28 | ALA5154659 | cell membrane format | Scientific Literature | |
6. | ALA5155956 | Binding | Displacement of [3H]-2-p-2-(carboxyethyl)phenyl-ethylamino-5'-N-ethylcarboxamidoadenosine from human A2A receptor stably expressed in HEK293 cell membrane by radioligand inhibition assay | Homo sapiens | 7 | ALA5154659 | cell membrane format | Scientific Literature | |
7. | ALA5155957 | Binding | Displacement of [125I] N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from human A3A receptor stably expressed in HEK293 cell membrane by radioligand inhibition assay | Homo sapiens | 31 | ALA5154659 | cell membrane format | Scientific Literature | |
8. | ALA5155958 | Functional | Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based NanoBiT assay | Homo sapiens | 11 | ALA5154659 | cell-based format | Scientific Literature | |
9. | ALA5155959 | Functional | Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment maximum efficacy by luciferase based NanoBiT assay | Homo sapiens | 11 | ALA5154659 | cell-based format | Scientific Literature | |
10. | ALA5155960 | Functional | Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay | Homo sapiens | 11 | ALA5154659 | cell-based format | Scientific Literature | |
11. | ALA5155961 | Functional | Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment maximum efficacy by luciferase based NanoBiT assay | Homo sapiens | 11 | ALA5154659 | cell-based format | Scientific Literature | |
12. | ALA5155962 | ADME | Stability of the compound in simulated intestinal fluid assessed as parent compound remaining at 120 mins | 3 | ALA5154659 | assay format | Scientific Literature | ||
13. | ALA5155963 | ADME | Stability of the compound in simulated gastric fluid assessed as parent compound remaining at 120 mins | 3 | ALA5154659 | assay format | Scientific Literature | ||
14. | ALA5155964 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 3 | ALA5154659 | single protein format | Scientific Literature | |
15. | ALA5155965 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 3 | ALA5154659 | single protein format | Scientific Literature | |
16. | ALA5155966 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 3 | ALA5154659 | single protein format | Scientific Literature | |
17. | ALA5155967 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 3 | ALA5154659 | single protein format | Scientific Literature | |
18. | ALA5155968 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 3 | ALA5154659 | single protein format | Scientific Literature | |
19. | ALA5155969 | ADME | Stability in human plasma assessed as parent compound remaining measured after 120 mins | Homo sapiens | 3 | ALA5154659 | cell-free format | Scientific Literature | |
20. | ALA5155970 | ADME | Stability in Wistar rat plasma assessed as parent compound remaining measured after 120 mins | Rattus norvegicus | 3 | ALA5154659 | cell-free format | Scientific Literature |