| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5136927 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM incubated for 5 mins by microscale thermophoresis assay | Homo sapiens | 38 | assay format | Scientific Literature | ||
| 2. | ALA5136928 | B | Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using tRNA asp as substrate and SAM as co-substrate incubated for 5 mins by tritium incorporation assay relative to control | Homo sapiens | 38 | assay format | Scientific Literature | ||
| 3. | ALA5136929 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 4. | ALA5136930 | B | Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 5. | ALA5136931 | B | Selectivity ratio of Kd for binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as dissociation constant to IC50 for inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS | 4 | assay format | Scientific Literature | |||
| 6. | ALA5136932 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as gibbs free energy change at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 7. | ALA5136933 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as change in enthalpy change at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 8. | ALA5136934 | B | Binding affinity to full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS assessed as change in entropy at 100 uM by isothermal titration calorimetry assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 9. | ALA5136935 | B | Inhibition of recombinant human DNMT3A-3L expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using Poly(dI-dC)-Poly(dI-dC) as substrate measured at 150 mins by liquid scintillation counting analysis | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 10. | ALA5136936 | B | Inhibition of full length recombinant human NSUN2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM measured at 20 mins by liquid scintillation counting analysis | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 11. | ALA5136937 | B | Inhibition of full length human NSUN6 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM measured at 20 mins by liquid scintillation counting analysis | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 12. | ALA5136938 | B | Inhibition of recombinant human EHMT2 G9a expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM using histone H3 as substrate measured at 120 mins by liquid scintillation counting analysis | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 13. | ALA5136939 | B | Inhibition of full length human N-terminal his6-tagged DNMT2 expressed in Escherichia coli Rosetta2(DE3)pLysS at 100 uM by liquid scintillation counting analysis | Homo sapiens | 6 | assay format | Scientific Literature |
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