| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5149455 | B | Agonist activity at recombinant human CD137 expressed in Jurkat T cells co-expressing response element driven luciferase reporter gene co-cultured with Nectin-4 expressing mouse MC38 cells assessed as luminescence measured after 6 hrs by luciferase reporter gene based co-culture assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5149456 | B | Agonist activity at human CD137 expressed in human HT-1376 cells measured after 6 hrs by fluorescence microplate reader assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5149457 | B | Agonist activity at human CD137 expressed in human NCI-H292 cells measured after 6 hrs by fluorescence microplate reader assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5149462 | F | Antiinflammatory activity in human PBMC stimulated with anti-CD3-mediated CD137 expression in cocultured with HTI376 cell line assessed as increase in secretion of IFN gamma incubated for 48 hrs by Luminex assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5149463 | F | Antiinflammatory activity in human PBMC stimulated with anti-CD3-mediated CD137 expression in cocultured with HTI376 cell line assessed as increase in secretion of IL2 incubated for 48 hrs by Luminex assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5149473 | B | Binding affinity to human recombinant CD137 by surface plasmon resonance analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA5149478 | B | Binding affinity to human Nectin-4 assessed as dissociation constant using 1:1 Nectin-4/CD137 by surface plasmon resonance analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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