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# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5143789 | ADME | Metabolic stability in human liver assessed as intrinsic clearance at 100 uM incubated for 180 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 7 | ALA5143506 | tissue-based format | Scientific Literature | |
2. | ALA5143790 | Functional | Antiviral activity against wild type HIV-1 IIIB infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured after 5 days by MTT assay | Human immunodeficiency virus 1 | 17 | ALA5143506 | organism-based format | Scientific Literature | |
3. | ALA5143791 | Functional | Antiviral activity against wild type HIV-1 ROD infected in human MT4 cells assessed as protection against virus-induced cytopathic effect measured after 5 days by MTT assay | Human immunodeficiency virus 1 | 17 | ALA5143506 | organism-based format | Scientific Literature | |
4. | ALA5143792 | Toxicity | Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay | Homo sapiens | 17 | ALA5143506 | cell-based format | Scientific Literature | |
5. | ALA5143793 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against human MT4 cells to EC50 for antiviral activity against HIV-1 IIIB infected in human MT4 cells | 17 | ALA5143506 | cell-based format | Scientific Literature | ||
6. | ALA5143794 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against human MT4 cells to EC50 for antiviral activity against HIV-1 ROD infected in human MT4 cells | 17 | ALA5143506 | cell-based format | Scientific Literature | ||
7. | ALA5143795 | Binding | Binding affinity to HIV1 capsid protein monomer assessed as dissociation constant by SPR analysis | Human immunodeficiency virus 1 | 4 | ALA5143506 | single protein format | Scientific Literature | |
8. | ALA5143796 | Binding | Binding affinity to HIV1 capsid protein hexamer assessed as dissociation constant by SPR analysis | Human immunodeficiency virus 1 | 6 | ALA5143506 | single protein format | Scientific Literature | |
9. | ALA5143797 | Binding | Selectivity Ratio of Kd for Binding affinity to HIV1 capsid protein monomer to Binding affinity to HIV1 capsid protein hexamer | 4 | ALA5143506 | assay format | Scientific Literature | ||
10. | ALA5143798 | Functional | Antiviral activity against HIV1 NL4-3 Env-deficient pseudotype virus infected in human U87.CD4.CCR5.CXCR4 cells assessed by reduction in viral infection in early stage at 5 uM measured after 48 hrs by luciferase activity based single-round infection assay | Human immunodeficiency virus 1 | 1 | ALA5143506 | organism-based format | Scientific Literature | |
11. | ALA5143799 | Functional | Antiviral activity against HIV1 NL4-3 Env-deficient pseudotype virus infected in human U87.CD4.CCR5.CXCR4 cells assessed by reduction in viral infection in late stage at 5 uM measured after 48 hrs by luciferase activity based single-round infection assay | Human immunodeficiency virus 1 | 1 | ALA5143506 | organism-based format | Scientific Literature | |
12. | ALA5143802 | ADME | Metabolic stability in human liver microsomes assessed as half life at 100 uM incubated for 180 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 7 | ALA5143506 | microsome format | Scientific Literature | |
13. | ALA5143803 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 100 uM incubated for 180 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 7 | ALA5143506 | microsome format | Scientific Literature | |
14. | ALA5143804 | ADME | Metabolic stability in human liver microsome assessed as parent compound remaining at 100 uM measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 7 | ALA5143506 | microsome format | Scientific Literature | |
15. | ALA5143805 | ADME | Metabolic stability in human liver microsome assessed as parent compound remaining at 100 uM measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA5143506 | microsome format | Scientific Literature | |
16. | ALA5143806 | ADME | Metabolic stability in human plasma assessed as parent compound remaining at 100 uM incubated for 120 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA5143506 | cell-free format | Scientific Literature | |
17. | ALA5143807 | Binding | Displacement of CPSF6 peptide from HIV1 capsid protein by surface plasmon resonance-based competition assay | Human immunodeficiency virus 1 | 2 | ALA5143506 | single protein format | Scientific Literature | |
18. | ALA5143808 | Binding | Displacement of NUP153 peptide from HIV1 capsid protein by surface plasmon resonance-based competition assay | Human immunodeficiency virus 1 | 2 | ALA5143506 | single protein format | Scientific Literature | |
19. | ALA5143809 | Binding | Binding affinity to HIV1 capsid protein hexamer assessed as rate constant (koff) by SPR analysis | Human immunodeficiency virus 1 | 4 | ALA5143506 | single protein format | Scientific Literature |