# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5160877 | Binding | Protac activity at VHL/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation at 100 nM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 17 | ALA5154782 | cell-based format | Scientific Literature | |
2. | ALA5160887 | Binding | Protac activity at VHL/EGFR L858R/T790M mutant (unknown origin) assessed as inhibition of EGFR incubated for 40 mins in presence of ATP by Kinase Glo luminescence assay | Homo sapiens | 7 | ALA5154782 | protein format | Scientific Literature | |
3. | ALA5160913 | Functional | Antiproliferative activity against human NCI-H1975 cells expressing EGFR L858R/T790M mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 35 | ALA5154782 | cell-based format | Scientific Literature | |
4. | ALA5160914 | Functional | Antiproliferative activity against human HCC827 cells expressing EGFR deletion19 mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 33 | ALA5154782 | cell-based format | Scientific Literature | |
5. | ALA5160916 | Binding | Protac activity at VHL/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation at 1000 nM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA5154782 | cell-based format | Scientific Literature | |
6. | ALA5160917 | Binding | Protac activity at VHL/EGFR L858R/T790M mutant in human HCC827 cells assessed as induction of EGFR degradation at 100 nM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA5154782 | cell-based format | Scientific Literature | |
7. | ALA5160918 | Binding | Protac activity at VHL/EGFR L858R/T790M mutant in human HCC827 cells assessed as induction of EGFR degradation at 1000 nM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA5154782 | cell-based format | Scientific Literature |