# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5112348 | B | Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by RapidFire Mass Spectrometry kinase assay | Homo sapiens | 21 | ALA5108064 | single protein format | Scientific Literature | |
2. | ALA5112349 | B | Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by RapidFire Mass Spectrometry kinase assay | Homo sapiens | 21 | ALA5108064 | single protein format | Scientific Literature | |
3. | ALA5112350 | B | Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by RapidFire Mass Spectrometry kinase assay | Homo sapiens | 21 | ALA5108064 | single protein format | Scientific Literature | |
4. | ALA5112351 | B | Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by RapidFire Mass Spectrometry kinase assay | Homo sapiens | 21 | ALA5108064 | single protein format | Scientific Literature | |
5. | ALA5112352 | B | Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay | Homo sapiens | 17 | ALA5108064 | cell-based format | Scientific Literature | |
6. | ALA5112353 | B | Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay | Homo sapiens | 17 | ALA5108064 | cell-based format | Scientific Literature | |
7. | ALA5112354 | B | Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureFire assay | Homo sapiens | 17 | ALA5108064 | cell-based format | Scientific Literature | |
8. | ALA5112355 | P | Aqueous solubility of the compound at pH 7 | 7 | ALA5108064 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5112356 | A | Microsomal stability in rat liver microsomes assessed as intrinsic clearance at 4 uM incubated for 30 mins in presence of NADPH by LCMS/MS analysis | Rattus norvegicus | 7 | ALA5108064 | microsome format | Scientific Literature | |
10. | ALA5112357 | A | Microsomal stability in human liver microsomes assessed as intrinsic clearance at 4 uM incubated for 30 mins in presence of NADPH by LCMS/MS analysis | Homo sapiens | 7 | ALA5108064 | microsome format | Scientific Literature | |
11. | ALA5112358 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LCMS/MS analysis | Rattus norvegicus | 3 | ALA5108064 | organism-based format | Scientific Literature | |
12. | ALA5112361 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LCMS/MS analysis | Rattus norvegicus | 3 | ALA5108064 | organism-based format | Scientific Literature | |
13. | ALA5112364 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LCMS/MS analysis | Rattus norvegicus | 3 | ALA5108064 | organism-based format | Scientific Literature |