# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5109808 | Toxicity | Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Macaca mulatta | 13 | ALA5108005 | cell-based format | Scientific Literature | |
2. | ALA5109809 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in monkey LLC-MK2 cells assessed as reduction in cell death inducing capability incubated for 24 hrs by hemocytometer chamber based analysis | Trypanosoma cruzi | 12 | ALA5108005 | organism-based format | Scientific Literature | |
3. | ALA5109810 | Toxicity | Selectivity index, ratio of EC50 for Cytotoxicity against monkey LLC-MK2 cells to EC50 for antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in monkey LLC-MK2 cells | 13 | ALA5108005 | cell-based format | Scientific Literature | ||
4. | ALA5109811 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as parasite growth inhibition measured after 24 hrs by hemocytometer chamber based analysis | Trypanosoma cruzi | 4 | ALA5108005 | organism-based format | Scientific Literature | |
5. | ALA5109812 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as parasite growth inhibition measured after 48 hrs by hemocytometer chamber based analysis | Trypanosoma cruzi | 4 | ALA5108005 | organism-based format | Scientific Literature | |
6. | ALA5109813 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as parasite growth inhibition measured after 72 hrs by hemocytometer chamber based analysis | Trypanosoma cruzi | 4 | ALA5108005 | organism-based format | Scientific Literature | |
7. | ALA5109814 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y amastigotes infected in monkey LLC-MK2 cells assessed as reduction in reduction in amastigotes per 100 cells measured after 24 hrs by Giemsa staining based analysis | Trypanosoma cruzi | 2 | ALA5108005 | organism-based format | Scientific Literature | |
8. | ALA5109815 | Toxicity | Selectivity index, ratio of EC50 for Cytotoxicity against monkey LLC-MK2 cells to EC50 for antitrypanosomal activity against Trypanosoma cruzi Y amastigotes infected in monkey LLC-MK2 cells assessed as reduction in reduction in amastigotes per 100 cells measured after 24 hrs by Giemsa staining based analysis | 2 | ALA5108005 | cell-based format | Scientific Literature | ||
9. | ALA5109816 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y amastigotes infected in monkey LLC-MK2 cells assessed as reduction in reduction in amastigotes per 100 cells measured after 48 hrs by Giemsa staining based analysis | Trypanosoma cruzi | 2 | ALA5108005 | organism-based format | Scientific Literature | |
10. | ALA5109817 | Toxicity | Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Macaca mulatta | 2 | ALA5108005 | cell-based format | Scientific Literature | |
11. | ALA5109818 | Toxicity | Selectivity index, ratio of EC50 for Cytotoxicity against monkey LLC-MK2 cells to EC50 for antitrypanosomal activity against Trypanosoma cruzi Y amastigotes infected in monkey LLC-MK2 cells assessed as reduction in reduction in amastigotes per 100 cells measured after 48 hrs by Giemsa staining based analysis | 2 | ALA5108005 | cell-based format | Scientific Literature | ||
12. | ALA5109823 | Functional | Induction of cell death in Trypanosoma cruzi Y epimastigotes assessed as live cells at 7.2 uM incubated for 24 hrs by Annexin V/7-AAD staining based flow cytometric analysis (Rvb = 98.6 %) | Trypanosoma cruzi | 1 | ALA5108005 | organism-based format | Scientific Literature | |
13. | ALA5109824 | Functional | Induction of cell death in Trypanosoma cruzi Y epimastigotes assessed as early apoptotic cells at 7.2 uM incubated for 24 hrs by Annexin V/7-AAD staining based flow cytometric analysis (Rvb = 0.11 %) | Trypanosoma cruzi | 1 | ALA5108005 | organism-based format | Scientific Literature | |
14. | ALA5109825 | Functional | Induction of cell death in Trypanosoma cruzi Y epimastigotes assessed as late apoptotic cells at 7.2 uM incubated for 24 hrs by Annexin V/7-AAD staining based flow cytometric analysis (Rvb = 0.12 %) | Trypanosoma cruzi | 1 | ALA5108005 | organism-based format | Scientific Literature | |
15. | ALA5109826 | Functional | Induction of cell death in Trypanosoma cruzi Y epimastigotes assessed as dead cells at 7.2 uM incubated for 24 hrs by Annexin V/7-AAD staining based flow cytometric analysis (Rvb = 1.13 %) | Trypanosoma cruzi | 1 | ALA5108005 | organism-based format | Scientific Literature | |
16. | ALA5109831 | Functional | Induction of oxidative stress in Trypanosoma cruzi Y epimastigotes assessed as increase in ROS formation at 7.2 uM incubated for 24 hrs by DCFH-DA staining based analysis relative to control | Trypanosoma cruzi | 1 | ALA5108005 | organism-based format | Scientific Literature | |
17. | ALA5109833 | Functional | Induction of mitochondrial membrane potential loss in Trypanosoma cruzi Y epimastigotes at 7.2 uM incubated for 24 hrs by Rhodamine 123 staining based flow cytometric analysis relative to control | Trypanosoma cruzi | 1 | ALA5108005 | organism-based format | Scientific Literature | |
18. | ALA5109836 | Binding | Induction of membrane damage in Trypanosoma cruzi Y epimastigotes at EC50 measured after 12 hrs by SEM analysis | Trypanosoma cruzi | 2 | ALA5108005 | organism-based format | Scientific Literature |