| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5100323 | B | Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr by HTRF assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 2. | ALA5100325 | B | Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr by HTRF assay | Homo sapiens | 29 | single protein format | Scientific Literature | ||
| 3. | ALA5100326 | B | Inhibition of recombinant human FGFR3 V555M mutant using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr by HTRF assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 4. | ALA5100327 | B | Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate reader analysis | Mus musculus | 14 | cell-based format | Scientific Literature | ||
| 5. | ALA5100332 | A | Apparent permeability in human Caco-2 cells at 50 uM incubated for 120 mins by LC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 6. | ALA5100333 | A | Metabolic stability in human liver microsomes assessed as clearance at 1 uM preincubated for 2 mins followed by NADPH addition and measured upto 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 7. | ALA5100334 | P | Solubility of compound in FaSSIF by HPLC assay | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5100335 | P | Solubility of compound in SGF by HPLC assay | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA5100336 | B | Inhibition of human liver microsomes CYP3A4 using midazolam or testosterone as substrate in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 10. | ALA5100344 | B | Selectivity ratio of IC50 for recombinant human FGFR1 to IC50 for recombinant human FGFR3 | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 11. | ALA5100347 | F | Invivo inhibition of ERK phosphorylation in human UMUC14 cells xenografted with NSG mouse at 100 mg/kg, po measured after 2 hrs by MSD assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5100348 | F | Induction of phosphorus increase in human UMUC14 cells xenografted with C57BL/6 mouse at 10 to 100 mg/kg, po measured after 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature |
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