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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA5140186 B Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using Boc-VPR-AMC as fluorogenic substrate incubated for 30 mins by fluorescence plate reader assay Homo sapiens 22 ALA5137037 cell-based format Scientific Literature 2. ALA5140188 A Stability of the compound in human plasma assessed as half life measured after 30 mins by LC-MS analysis Homo sapiens 8 ALA5137037 cell-free format Scientific Literature 3. ALA5140189 B Binding affinity to human serum albumin by fluorescence polarization assay Homo sapiens 6 ALA5137037 single protein format Scientific Literature 4. ALA5140190 B Binding affinity to mouse serum albumin by fluorescence polarization assay Mus musculus 1 ALA5137037 single protein format Scientific Literature 5. ALA5140191 B Inhibition of mouse KLK5 assessed as inhibition constant using Boc-VPR-AMC as fluorogenic substrate incubated for 30 mins by fluorescence plate reader assay Mus musculus 1 ALA5137037 cell-based format Scientific Literature 6. ALA5140192 B Inhibition of mouse KLK7 assessed as inhibition constant Mus musculus 1 ALA5137037 cell-based format Scientific Literature 7. ALA5140193 A Plasma concentration in C57BL/6J mouse at 6.2 mg/kg, ip measured upto 24 hrs by RP-HPLC analysis Mus musculus 2 ALA5137037 organism-based format Scientific Literature 8. ALA5140194 A Half life in C57BL/6J mouse at 6.2 mg/kg, ip by RP-HPLC analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 9. ALA5140195 A Drug uptake in C57BL/6J mouse skin at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 10. ALA5140196 A Half life in C57BL/6J mouse at 6.2 mg/kg, sc by RP-HPLC analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 11. ALA5140197 A Drug degradation in C57BL/6J mouse at 6.2 mg/kg, ip measured after 18 to 28 mins by RP-HPLC analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 12. ALA5140198 A Drug degradation in C57BL/6J mouse at 6.2 mg/kg, iv measured at 21 to 22 mins by RP-HPLC analysis Mus musculus 2 ALA5137037 organism-based format Scientific Literature 13. ALA5140199 A Drug degradation in C57BL/6J mouse at 6.2 mg/kg, sc measured after 18 to 28 mins by RP-HPLC analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 14. ALA5140200 A Drug uptake in C57BL/6J mouse skin epidermis at 6.2 mg/kg, iv measured after 8 hrs by fluorescence imaging analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 15. ALA5140202 A Drug uptake in C57BL/6J mouse heart at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 16. ALA5140203 A Drug uptake in C57BL/6J mouse lung at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 17. ALA5140204 A Drug uptake in C57BL/6J mouse liver at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 18. ALA5140205 A Drug uptake in C57BL/6J mouse kidney at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 19. ALA5140206 A Drug uptake in C57BL/6J mouse spleen at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis Mus musculus 1 ALA5137037 organism-based format Scientific Literature 20. ALA5140208 A Half life in C57BL/6J mouse at 6.2 mg/kg, iv by RP-HPLC analysis Mus musculus 2 ALA5137037 organism-based format Scientific Literature