| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5140186 | B | Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using Boc-VPR-AMC as fluorogenic substrate incubated for 30 mins by fluorescence plate reader assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA5140188 | A | Stability of the compound in human plasma assessed as half life measured after 30 mins by LC-MS analysis | Homo sapiens | 8 | cell-free format | Scientific Literature | ||
| 3. | ALA5140189 | B | Binding affinity to human serum albumin by fluorescence polarization assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 4. | ALA5140190 | B | Binding affinity to mouse serum albumin by fluorescence polarization assay | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 5. | ALA5140191 | B | Inhibition of mouse KLK5 assessed as inhibition constant using Boc-VPR-AMC as fluorogenic substrate incubated for 30 mins by fluorescence plate reader assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5140192 | B | Inhibition of mouse KLK7 assessed as inhibition constant | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5140193 | A | Plasma concentration in C57BL/6J mouse at 6.2 mg/kg, ip measured upto 24 hrs by RP-HPLC analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA5140194 | A | Half life in C57BL/6J mouse at 6.2 mg/kg, ip by RP-HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA5140195 | A | Drug uptake in C57BL/6J mouse skin at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5140196 | A | Half life in C57BL/6J mouse at 6.2 mg/kg, sc by RP-HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5140197 | A | Drug degradation in C57BL/6J mouse at 6.2 mg/kg, ip measured after 18 to 28 mins by RP-HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5140198 | A | Drug degradation in C57BL/6J mouse at 6.2 mg/kg, iv measured at 21 to 22 mins by RP-HPLC analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA5140199 | A | Drug degradation in C57BL/6J mouse at 6.2 mg/kg, sc measured after 18 to 28 mins by RP-HPLC analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5140200 | A | Drug uptake in C57BL/6J mouse skin epidermis at 6.2 mg/kg, iv measured after 8 hrs by fluorescence imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5140202 | A | Drug uptake in C57BL/6J mouse heart at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5140203 | A | Drug uptake in C57BL/6J mouse lung at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5140204 | A | Drug uptake in C57BL/6J mouse liver at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5140205 | A | Drug uptake in C57BL/6J mouse kidney at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5140206 | A | Drug uptake in C57BL/6J mouse spleen at 12.4 mg/kg, ip measured after 48 hrs by fluorescence imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5140208 | A | Half life in C57BL/6J mouse at 6.2 mg/kg, iv by RP-HPLC analysis | Mus musculus | 2 | organism-based format | Scientific Literature |
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