# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5152430 | Binding | Antagonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 1 uM by two-electrode voltage clamp method | Homo sapiens | 2 | ALA5150017 | cell-based format | Scientific Literature | |
2. | ALA5152443 | Binding | Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential by two-electrode voltage clamp method | Homo sapiens | 4 | ALA5150017 | cell-based format | Scientific Literature | |
3. | ALA5152444 | Binding | Antagonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential by two-electrode voltage clamp method | Homo sapiens | 2 | ALA5150017 | cell-based format | Scientific Literature | |
4. | ALA5152445 | Binding | Antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude by two-electrode voltage clamp method | Rattus norvegicus | 2 | ALA5150017 | cell-based format | Scientific Literature | |
5. | ALA5152446 | Binding | Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 100 nM by two-electrode voltage clamp method | Homo sapiens | 26 | ALA5150017 | cell-based format | Scientific Literature | |
6. | ALA5152447 | Binding | Antagonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 100 nM by two-electrode voltage clamp method | Homo sapiens | 1 | ALA5150017 | cell-based format | Scientific Literature | |
7. | ALA5152448 | Binding | Antagonist activity at human alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 100 nM by two-electrode voltage clamp method | Homo sapiens | 1 | ALA5150017 | cell-based format | Scientific Literature | |
8. | ALA5152449 | Binding | Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential in presence of BAPTA-AM at 100 nM by two-electrode voltage clamp method | Homo sapiens | 1 | ALA5150017 | cell-based format | Scientific Literature | |
9. | ALA5152450 | Binding | Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 100 nM by two-electrode voltage clamp method | Homo sapiens | 1 | ALA5150017 | cell-based format | Scientific Literature | |
10. | ALA5152451 | Binding | Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential by two-electrode voltage clamp method | Homo sapiens | 1 | ALA5150017 | cell-based format | Scientific Literature | |
11. | ALA5152452 | Binding | Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential in presence of BAPTA-AM by two-electrode voltage clamp method | Homo sapiens | 1 | ALA5150017 | cell-based format | Scientific Literature | |
12. | ALA5152453 | Functional | Analgesic activity in chronic constriction injury-induced mechanical pain rat model assessed as increase in paw withdrawal latency measured after 24 hrs | Rattus norvegicus | 1 | ALA5150017 | organism-based format | Scientific Literature | |
13. | ALA5152454 | Functional | Analgesic activity in chronic constriction injury-induced mechanical pain mouse model assessed as increase in paw withdrawal latency at 25 ug/kg measured after 24 hrs | Mus musculus | 1 | ALA5150017 | organism-based format | Scientific Literature | |
14. | ALA5152455 | Functional | Analgesic activity in chronic constriction injury-induced mechanical pain mouse model assessed as increase in paw withdrawal latency at 0.5 ug/kg measured after 12 hrs | Mus musculus | 1 | ALA5150017 | organism-based format | Scientific Literature | |
15. | ALA5152456 | Functional | Analgesic activity in chronic constriction injury-induced mechanical pain mouse model assessed as increase in paw withdrawal latency at 2.5 ug/kg measured after 12 hrs | Mus musculus | 1 | ALA5150017 | organism-based format | Scientific Literature | |
16. | ALA5152458 | Toxicity | Toxicity in mouse assessed as abnormal motor behavior | Mus musculus | 1 | ALA5150017 | assay format | Scientific Literature |