# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5112574 | B | Inhibition of recombinant human sEH using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate incubated for 5 mins | Homo sapiens | 19 | single protein format | Scientific Literature | ||
2. | ALA5112575 | B | Inhibition of mouse sEH in using using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate incubated for 5 mins | Mus musculus | 19 | single protein format | Scientific Literature | ||
3. | ALA5112576 | A | Microsomal stability in human recombinant microsomes assessed as parent compound remaining in the presence of NADPH measured after 60 mins by UPLC-MS/MS analysis relative to control | Homo sapiens | 18 | microsome format | Scientific Literature | ||
4. | ALA5112577 | A | Microsomal stability in mouse microsomes assessed as parent compound remaining in the presence of NADPH measured after 60 mins by UPLC-MS/MS analysis relative to control | Mus musculus | 18 | microsome format | Scientific Literature | ||
5. | ALA5112578 | P | Solubility of the compound in PBS buffer incubated for 2 hrs by nephelometry reader analysis | 9 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA5112579 | F | Cytotoxicity against human SH-SY5Y cells assessed as cell death incubated for 24 hrs by propidium iodide fluorescence stain assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
7. | ALA5112580 | F | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
8. | ALA5112581 | A | Inhibition of human recombinant CYP2C9 at 10 uM using 7-methoxy-4(trifluoromethyl coumarin) as a substrate preincubated for 5 mins followed by substrate addition by fluorescence plate reader analysis relative to control | Homo sapiens | 9 | single protein format | Scientific Literature | ||
9. | ALA5112582 | A | Inhibition of human recombinant CYP2C19 at 10 uM using 3-cyano-7-ethoxycoumarin as a substrate preincubated for 5 mins followed by substrate addition by fluorescence plate reader analysis relative to control | Homo sapiens | 5 | single protein format | Scientific Literature | ||
10. | ALA5112584 | A | Inhibition of human recombinant CYP2C19 at 10 uM using 7-BFC and DBF as a substrate preincubated for 5 mins followed by substrate addition by fluorescence plate reader analysis relative to control | Homo sapiens | 8 | assay format | Scientific Literature | ||
11. | ALA5112587 | A | Permeability across apical to basal membrane in human Caco-2 cells at 10 uM measured after 2 hrs by UPLC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
12. | ALA5112588 | A | Permeability across basal to apical membrane in human Caco-2 cells at 10 uM measured after 2 hrs by UPLC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA5112589 | A | Efflux ratio of permeability across basolateral to apical membrane over apical to basolateral membrane in human Caco-2 cells after 2 hrs by LC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA5112590 | T | Inhibition of hERG transfected in CHO cells at 10 uM incubated for 30 mins by FluxorTM Potassium Ion Chanel Assay Kit method relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
15. | ALA5112591 | B | Inhibition of human recombinant LOX-5 using arachidonic acid and ATP as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins by fluorescent assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
16. | ALA5112592 | B | Inhibition of human recombinant COX-2 using Arachidonic acid as substrate incubated for 5 mins | Homo sapiens | 3 | single protein format | Scientific Literature | ||
17. | ALA5112593 | A | Half life in CD-1 mouse plasma at 5 mg/kg, sc measured for 0.25 to 6 hrs by HPLC analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
18. | ALA5112594 | A | Tmax in CD-1 mouse plasma at 5 mg/kg, sc measured for 0.25 to 6 hrs by HPLC analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
19. | ALA5112595 | A | Cmax in CD-1 mouse plasma at 5 mg/kg, sc measured for 0.25 to 6 hrs by HPLC analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
20. | ALA5112596 | A | AUClast in CD-1 mouse plasma at 5 mg/kg, sc measured for 0.25 to 6 hrs by HPLC analysis | Mus musculus | 2 | organism-based format | Scientific Literature |