# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5160794 | B | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 10 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
2. | ALA5160795 | B | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 20 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
3. | ALA5160796 | B | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 40 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
4. | ALA5160797 | B | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 80 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
5. | ALA5160798 | B | Activation of Nrf2-ARE pathway in human HepG2-ARE-C8 cells assessed as fold upregulation of ARE-inducing luciferase activity at 160 uM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
6. | ALA5160799 | B | Activation of Nrf2 in rat PC-12 cells assessed as upregulation of HO-1 protein expression measured after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
7. | ALA5160800 | B | Activation of Nrf2 in rat PC-12 cells assessed as upregulation of NQO1 protein expression measured after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
8. | ALA5160801 | B | Activation of Nrf2 in rat PC-12 cells assessed as upregulation of Nrf2 protein expression measured after 24 hrs by Western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
9. | ALA5160803 | F | Antiinflammatory activity in PMA-differentiated and LPS-stimulated human THP-1 cell model assessed as inhibition of NLRP3 inflammasome-driven IL-1beta production at 15 uM incubated for 24 hrs followed by LPS stimulation for 3 hrs and ATP addition for 1 hr by ELISA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
10. | ALA5160804 | F | Antiinflammatory activity in PMA-differentiated and LPS-stimulated human THP-1 cell model assessed as inhibition of NLRP3 inflammasome-driven IL-1beta production at 30 uM incubated for 24 hrs followed by LPS stimulation for 3 hrs and ATP addition for 1 hr by ELISA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
11. | ALA5160805 | F | Antiinflammatory activity in PMA-differentiated and LPS-stimulated human THP-1 cell model assessed as inhibition of NLRP3 inflammasome-driven IL-1beta production at 45 uM incubated for 24 hrs followed by LPS stimulation for 3 hrs and ATP addition for 1 hr by ELISA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
12. | ALA5160806 | T | Cytotoxicity against human THP-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
13. | ALA5160816 | B | Activation of Nrf2 in rat PC-12 cells assessed as reduction of Nrf2 in cytoplasm at 20 uM measured after 4 hrs by western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
14. | ALA5160817 | B | Activation of Nrf2 in rat PC-12 cells assessed as upregulation of Nrf2 in nucleus at 20 uM measured after 4 hrs by western blot analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature |