| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5164516 | F | Antagonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by Fluo-4AM staining based fluorescence assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 2. | ALA5164517 | F | Antagonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by by Fluo-4AM staining based fluorescence assay | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 3. | ALA5164518 | F | Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as intracellular calcium mobilization by calcium mobilization assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA5164519 | F | Antagonist activity at human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as intracellular calcium mobilization by calcium mobilization assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5164520 | F | Antagonist activity at human muscarinic M3 receptor expressed in CHO cells co-expressing Gqi5 assessed as intracellular calcium mobilization by calcium mobilization assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5164526 | B | Selectivity index, ratio of IC50 for human muscarinic M1 receptor expressed in CHO cells to IC50 for human muscarinic M5 receptor expressed in CHO cells | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 7. | ALA5164527 | F | Antagonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by by Fluo-4AM staining based fluorescence assay relative to control | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
| 8. | ALA5164528 | F | Antagonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by by Fluo-4AM staining based fluorescence assay relative to control | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 9. | ALA5164529 | A | Brain to plasma concentration ratio in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 10. | ALA5164530 | A | Unbound brain-to-plasma concentration ratio in Sprague-Dawley rat at 0.2 mg/kg, iv administered as cassette dose | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 11. | ALA5164531 | A | Intrinsic clearance in Sprague-Dawley rat hepatic microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured upto 45 mins by LC/MS/MS analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 12. | ALA5164532 | A | Intrinsic clearance in human hepatic microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured upto 45 mins by LC/MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 13. | ALA5164533 | A | Protein binding in Sprague-Dawley rat plasma assessed as unbound fraction at 5 uM incubated for 6 hrs by rapid equlibrium dialysis based LC/MS/MS analysis | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 14. | ALA5164534 | A | Protein binding in Sprague-Dawley rat brain assessed as unbound fraction at 1 uM incubated for 6 hrs by rapid equlibrium dialysis based LC/MS/MS analysis | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA5164535 | A | Protein binding in human plasma assessed as unbound fraction at 5 uM incubated for 6 hrs by rapid equlibrium dialysis based LC/MS/MS analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 16. | ALA5164536 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 17. | ALA5164537 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 18. | ALA5164538 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 19. | ALA5164539 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 20. | ALA5164540 | A | Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv measured up to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!