# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5135115 | Binding | Binding affinity to RNase L (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as thermal stability by measuring melting temperature at 60 uM incubated for 50 mins by NanoDSF analysis | Homo sapiens | 14 | ALA5131493 | assay format | Scientific Literature | |
2. | ALA5135116 | Functional | Antiproliferative activity against human JAR cells assessed as cell growth inhibition at 10 uM incubated for 72 hrs by MTT assay relative to control | Homo sapiens | 41 | ALA5131493 | cell-based format | Scientific Literature | |
3. | ALA5135124 | Functional | Antiproliferative activity against human JAR cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | Homo sapiens | 27 | ALA5131493 | cell-based format | Scientific Literature | |
4. | ALA5135125 | Functional | Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | Homo sapiens | 25 | ALA5131493 | cell-based format | Scientific Literature | |
5. | ALA5135126 | Functional | Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | Homo sapiens | 17 | ALA5131493 | cell-based format | Scientific Literature | |
6. | ALA5135127 | Functional | Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay | Homo sapiens | 11 | ALA5131493 | cell-based format | Scientific Literature | |
7. | ALA5135128 | Functional | Induction of apoptosis in human JAR cells assessed as fold increase in cleaved PARP level at 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA5131493 | cell-based format | Scientific Literature | |
8. | ALA5135129 | Functional | Induction of apoptosis in human JAR cells assessed as fold increase in PARP cleavage at 5 to10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
9. | ALA5135130 | Functional | Induction of apoptosis in human JAR cells assessed as live cells at 5 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 79.87%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
10. | ALA5135131 | Functional | Induction of apoptosis in human JAR cells assessed as early apoptotic cells at 5 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 8.24%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
11. | ALA5135132 | Functional | Induction of apoptosis in human JAR cells assessed as late apoptotic cells at 5 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 11.67%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
12. | ALA5135133 | Functional | Induction of apoptosis in human JAR cells assessed as necrotic cells at 5 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0.22%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
13. | ALA5135134 | Functional | Induction of apoptosis in human JAR cells assessed as live cells at 10 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 79.87%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
14. | ALA5135135 | Functional | Induction of apoptosis in human JAR cells assessed as early apoptotic cells at 10 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 8.24%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
15. | ALA5135136 | Functional | Induction of apoptosis in human JAR cells assessed as late apoptotic cells at 10 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 11.67%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
16. | ALA5135137 | Functional | Induction of apoptosis in human JAR cells assessed as necrotic cells at 10 uM measured after 72 hrs by Annexin V-FITC/PI staining based flow cytometry (Rvb = 0.22%) | Homo sapiens | 1 | ALA5131493 | cell-based format | Scientific Literature | |
17. | ALA5135138 | Functional | Inhibition of cell migration in human JAR cells measured upto 72 hrs by scratch wound healing assay | Homo sapiens | 2 | ALA5131493 | cell-based format | Scientific Literature | |
18. | ALA5135139 | Functional | Inhibition of cell migration in human JAR cells at 5 uM measured after 72 hrs by scratch wound healing assay relative to control | Homo sapiens | 2 | ALA5131493 | cell-based format | Scientific Literature | |
19. | ALA5135140 | Functional | Inhibition of colony formation in human JAR cells measured after 3 days by Giemsa staining based microscopic analysis | Homo sapiens | 2 | ALA5131493 | cell-based format | Scientific Literature | |
20. | ALA5135141 | Functional | Inhibition of colony formation in human JAR cells assessed as cell reproductive death at upto 5 uM measured after 3 days by Giemsa staining based microscopic analysis | Homo sapiens | 2 | ALA5131493 | cell-based format | Scientific Literature |