| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5130122 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal at 10 uM by FluxOR fluorescent dye based assay | Homo sapiens | 29 | ALA5126610 | cell-based format | Scientific Literature | |
| 2. | ALA5130123 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal by FluxOR fluorescent dye based assay | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
| 3. | ALA5130125 | A | Metabolic stability in human liver S9 fraction assessed as phase 1 metabolism by UHPLC-MS/MS analysis | Homo sapiens | 4 | ALA5126610 | subcellular format | Scientific Literature | |
| 4. | ALA5130126 | A | Metabolic stability in human liver S9 fraction assessed as phase 2 metabolism by UHPLC-MS/MS analysis | Homo sapiens | 4 | ALA5126610 | subcellular format | Scientific Literature | |
| 5. | ALA5130127 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 1 | ALA5126610 | cell-based format | Scientific Literature | |
| 6. | ALA5130128 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as leftward shift change in half activation potential at 1 uM measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
| 7. | ALA5130129 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -80 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
| 8. | ALA5130130 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -120 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
| 9. | ALA5130131 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at + 80 mV assessed as leftward shift change in half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
| 10. | ALA5130132 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as fold change in maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method relative to control | Homo sapiens | 3 | ALA5126610 | cell-based format | Scientific Literature | |
| 11. | ALA5130133 | B | Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 2 | ALA5126610 | cell-based format | Scientific Literature | |
| 12. | ALA5130134 | B | Potency index, ratio of retigabine EC50 to test compound EC50 for anticonvulsant activity in Kv7.2/Kv7.3 (unknown origin) channel expressed in CHO cells | Homo sapiens | 1 | ALA5126610 | cell-based format | Scientific Literature | |
| 13. | ALA5130135 | B | Activation of Kv7 W236L mutant channel (unknown origin) expressed in CHO cells at 1 uM measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 1 | ALA5126610 | cell-based format | Scientific Literature | |
| 14. | ALA5130136 | B | Activation of Kv7 S303A mutant channel (unknown origin) expressed in CHO cells at 1 uM measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 1 | ALA5126610 | cell-based format | Scientific Literature | |
| 15. | ALA5130137 | B | Activation of Kv7.4 channel (unknown origin) expressed in CHO cells assessed as change in half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method | Homo sapiens | 1 | ALA5126610 | cell-based format | Scientific Literature | |
| 16. | ALA5130138 | B | Activation of Kv7.4 channel (unknown origin) expressed in CHO cells assessed as fold change in maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method relative to control | Homo sapiens | 1 | ALA5126610 | cell-based format | Scientific Literature | |
| 17. | ALA5130142 | F | Anticonvulsant activity in PTZ induced C57BL/6 mouse acute seizure model assessed as time for maximal seizure at 0.3 mg/kg, ip pretreated for 30 mins followed by PTZ injection and measured upto 30 mins by Liittjohann's scale analysis | Mus musculus | 1 | ALA5126610 | organism-based format | Scientific Literature | |
| 18. | ALA5130143 | F | Anticonvulsant activity in PTZ induced C57BL/6 mouse acute seizure model assessed as seizure score at 0.3 mg/kg, ip pretreated for 30 mins followed by PTZ injection and measured upto 30 mins by Liittjohann's scale analysis | Mus musculus | 1 | ALA5126610 | organism-based format | Scientific Literature | |
| 19. | ALA5130144 | F | Anticonvulsant activity in PTZ induced C57BL/6 mouse acute seizure model assessed as latency to maximal seizure at 3 mg/kg, ip pretreated for 30 mins followed by PTZ injection and measured upto 30 mins in presence of XE991 by Liittjohann's scale analysis | Mus musculus | 1 | ALA5126610 | organism-based format | Scientific Literature | |
| 20. | ALA5130145 | F | Anticonvulsant activity in PTZ induced C57BL/6 mouse acute seizure model assessed as seizure score at 3 mg/kg, ip pretreated for 30 mins followed by PTZ injection and measured upto 30 mins in presence of XE991 by Liittjohann's scale analysis | Mus musculus | 1 | ALA5126610 | organism-based format | Scientific Literature |
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