# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5106865 | Binding | Inhibition of human recombinant MMP-7 (Leu18 to Lys267 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 15 | ALA5104183 | single protein format | Scientific Literature | |
2. | ALA5106866 | Binding | Inhibition of human recombinant MMP-2 ( Ile34 to Cys660 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
3. | ALA5106867 | Binding | Inhibition of human recombinant MMP-1 (Phe20 to Asn469 residue) using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
4. | ALA5106868 | Binding | Inhibition of human recombinant MMP-3 (Tyr18 to Cys477 residues ) using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
5. | ALA5106869 | Binding | Inhibition of human recombinant MMP-8 (Phe21 to Gly467 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
6. | ALA5106870 | Binding | Inhibition of human recombinant MMP-9 (Ala20 to Asp707 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
7. | ALA5106871 | Binding | Inhibition of human recombinant MMP-12 (Leu17 to Cys470 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
8. | ALA5106872 | Binding | Inhibition of human recombinant MMP-13 (Leu20 to Cys471 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
9. | ALA5106873 | Binding | Inhibition of human recombinant C-terminal 10-His tagged MMP-14 ( Ala21 to Gly284 residues) using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis | Homo sapiens | 6 | ALA5104183 | single protein format | Scientific Literature | |
10. | ALA5106874 | ADME | Stability in human liver microsomes at 1 uM incubated for 15 mins by by liquid chromatography-mass spectrometry | Homo sapiens | 2 | ALA5104183 | microsome format | Scientific Literature | |
11. | ALA5106875 | ADME | Stability in human serum incubated for 4 hrs by liquid chromatography-tandem mass spectrometry | Homo sapiens | 2 | ALA5104183 | cell-free format | Scientific Literature | |
12. | ALA5106876 | Binding | Selectivity index, ratio of IC50 for human recombinant MMP-12 to IC50 for human recombinant MMP-7 | Homo sapiens | 1 | ALA5104183 | assay format | Scientific Literature | |
13. | ALA5106877 | Binding | Selectivity index, ratio of IC50 for human recombinant MMP-14 to IC50 for human recombinant MMP-7 | Homo sapiens | 1 | ALA5104183 | assay format | Scientific Literature |