# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5167628 | F | Antitumour activity against human Pfeiffer cells xenografted in nude mouse assessed as reduction in Ki67 expression in tumor at 75 mg/kg, po BID for 21 days by immunohistochemical analysis | Homo sapiens | 1 | ALA5154925 | organism-based format | Scientific Literature | |
2. | ALA5167629 | F | Antitumour activity against human Pfeiffer cells xenografted in nude mouse assessed as reduction in Ki67 expression in tumor at 5 mg/kg, ip BID for 21 days by immunohistochemical analysis | Homo sapiens | 1 | ALA5154925 | organism-based format | Scientific Literature | |
3. | ALA5167630 | A | Microsomal stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 4 | ALA5154925 | microsome format | Scientific Literature | |
4. | ALA5167631 | B | Inhibition of wild type partial length human PIK3CG (S144 to A1102 residues) expressed in mammalian cells assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA5154925 | cell-based format | Scientific Literature | |
5. | ALA5167632 | B | Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay | Homo sapiens | 30 | ALA5154925 | single protein format | Scientific Literature | |
6. | ALA5167633 | B | Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay | Homo sapiens | 30 | ALA5154925 | single protein format | Scientific Literature | |
7. | ALA5167634 | B | Selectivity ratio of IC50 for PI3Kalpha (unknown origin) to IC50 for PI3Kdelta (unknown origin) | Homo sapiens | 30 | ALA5154925 | assay format | Scientific Literature | |
8. | ALA5167635 | B | Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay | Homo sapiens | 4 | ALA5154925 | single protein format | Scientific Literature | |
9. | ALA5167636 | B | Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 1 hr in presence of ATP by ADP-glo luminescence assay | Homo sapiens | 4 | ALA5154925 | single protein format | Scientific Literature | |
10. | ALA5167637 | B | Inhibition of mTOR (unknown origin) | Homo sapiens | 4 | ALA5154925 | single protein format | Scientific Literature | |
11. | ALA5167638 | B | Inhibition of PI3Kdelta in IgM stimulated human Raji cells incubated for 10 mins by AlphaLISA assay | Homo sapiens | 4 | ALA5154925 | cell-based format | Scientific Literature | |
12. | ALA5167639 | B | Inhibition of PI3Kalpha in IGF-1 stimulated mouse C2C12 cells incubated for 10 mins by AlphaLISA assay | Mus musculus | 4 | ALA5154925 | cell-based format | Scientific Literature | |
13. | ALA5167640 | B | Inhibition of PI3Kbeta in LPA stimulated human PC-3 cells incubated for 10 mins by AlphaLISA assay | Homo sapiens | 4 | ALA5154925 | cell-based format | Scientific Literature | |
14. | ALA5167641 | B | Inhibition of PI3Kgamma in C5a stimulated mouse RAW264.7 cells incubated for 10 mins by AlphaLisa assay | Mus musculus | 4 | ALA5154925 | cell-based format | Scientific Literature | |
15. | ALA5167642 | F | Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 96 hrs by cell titer glo assay | Homo sapiens | 2 | ALA5154925 | cell-based format | Scientific Literature | |
16. | ALA5167643 | B | Inhibition of wild type partial length human PIK3CA (R108 to N1068 residues) expressed in mammalian cells assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA5154925 | cell-based format | Scientific Literature | |
17. | ALA5167644 | B | Inhibition of wild type full length human RSK2 (M1 to D394 residues) expressed in mammalian expression system assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA5154925 | assay format | Scientific Literature | |
18. | ALA5167645 | P | Solubility of the compound in PBS | 4 | ALA5154925 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA5167646 | A | Plasma protein binding in mouse | Mus musculus | 4 | ALA5154925 | cell-free format | Scientific Literature | |
20. | ALA5167647 | A | Microsomal stability in mouse liver microsomes assessed as half life | Mus musculus | 4 | ALA5154925 | microsome format | Scientific Literature |