# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5136536 | Toxicity | Inhibition of hERG cardiac ion channel | Homo sapiens | 13 | ALA5131562 | assay format | Scientific Literature | |
2. | ALA5136537 | Functional | Antibacterial activity against cystic fibrosis isolate Staphylococcus aureus by CLSI method | Staphylococcus aureus | 16 | ALA5131562 | organism-based format | Scientific Literature | |
3. | ALA5136538 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 29213 by CLSI method | Staphylococcus aureus | 16 | ALA5131562 | organism-based format | Scientific Literature | |
4. | ALA5136539 | Functional | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 by CLSI method | Staphylococcus aureus | 16 | ALA5131562 | organism-based format | Scientific Literature | |
5. | ALA5136540 | Functional | Antibacterial activity against Staphylococcus aureus 3527 by CLSI method | Staphylococcus aureus | 16 | ALA5131562 | organism-based format | Scientific Literature | |
6. | ALA5136541 | Functional | Antibacterial activity against Staphylococcus aureus harbouring GyrA D83N mutant by CLSI method | Staphylococcus aureus | 16 | ALA5131562 | organism-based format | Scientific Literature | |
7. | ALA5136542 | Binding | Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity incubated for 25 min by ethidium bromide/bromophenol blue staining based agarose gel electrophoresis analysis | Staphylococcus aureus | 15 | ALA5131562 | protein complex format | Scientific Literature | |
8. | ALA5136543 | Binding | Inhibition of Staphylococcus aureus DNA topoisomerase 4 decatenation activity using kDNA as substrate incubated for 10 to 20 min by ethidium bromide/bromophenol blue staining based agarose gel electrophoresis analysis | Staphylococcus aureus | 15 | ALA5131562 | protein complex format | Scientific Literature | |
9. | ALA5136544 | Binding | Selectivity ratio of IC50 for inhibition of Staphylococcus aureus DNA topoisomerase 4 decatenation activity to IC50 for inhibition of Staphylococcus aureus DNA gyrase supercoiling activity | Staphylococcus aureus | 15 | ALA5131562 | assay format | Scientific Literature | |
10. | ALA5136545 | Functional | Antimicrobial activity against Neisseria gonorrhoeae G strain harbouring type 2 topoisomerase GyrA S91F and ParE G410V mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
11. | ALA5136546 | Functional | Antimicrobial activity against wild type Neisseria gonorrhoeae ATCC 49226 incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
12. | ALA5136547 | Functional | Antimicrobial activity against wild type Neisseria gonorrhoeae F strain incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
13. | ALA5136548 | Functional | Antimicrobial activity against Neisseria gonorrhoeae K strain harbouring type 2 topoisomerase GyrA S91F, D95N and ParC S87R, S88P mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
14. | ALA5136549 | Functional | Antimicrobial activity against wild type Neisseria gonorrhoeae O strain incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
15. | ALA5136550 | Functional | Antimicrobial activity against wild type Neisseria gonorrhoeae P strain incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
16. | ALA5136551 | Functional | Antimicrobial activity against wild type Neisseria gonorrhoeae V strain harbouring type 2 topoisomerase GyrA S91F, D95G and ParC S87R mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
17. | ALA5136552 | Functional | Antimicrobial activity against wild type Neisseria gonorrhoeae Y strain harbouring type 2 topoisomerase GyrA S91F, D95G and ParC S87R mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | Neisseria gonorrhoeae | 21 | ALA5131562 | organism-based format | Scientific Literature | |
18. | ALA5136557 | ADME | Metabolic stability in mouse liver microsomes assessed as half life | Mus musculus | 13 | ALA5131562 | microsome format | Scientific Literature | |
19. | ALA5136558 | Toxicity | Inhibition of hERG cardiac ion channel at 200 uM relative to control | Homo sapiens | 2 | ALA5131562 | assay format | Scientific Literature | |
20. | ALA5136559 | Toxicity | Cytotoxicity activity against human K562 cells assessed as inhibition of cellular growth | Homo sapiens | 13 | ALA5131562 | cell-based format | Scientific Literature |