| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5156818 | B | Inhibition of recombinant human TTBK1 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATP | Homo sapiens | 50 | single protein format | Scientific Literature | ||
| 2. | ALA5156820 | B | Inhibition of recombinant human TTBK2 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATP | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 3. | ALA5156822 | B | Selectivity index, ratio of IC50 for recombinant human TTBK1 to IC50 for recombinant human TTBK2 | 48 | assay format | Scientific Literature | |||
| 4. | ALA5156823 | A | Permeability of the compound at pH 7.4 PBS/EtOH buffer (70:30) by PAMPA-BBB assay | 42 | assay format | Scientific Literature | |||
| 5. | ALA5156824 | F | Neuroprotective activity against ethacrynic acid-induced neurotoxicity human SH-SY5Y cells assessed as increase in cell viability at 5 uM preincubated for 1 hr followed by ethacrynic acid addition and further incubated for 24 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5156825 | F | Neuroprotective activity against ethacrynic acid-induced neurotoxicity human SH-SY5Y cells assessed as decrease in TDP-43 phosphorylation at Ser409 at 5 uM preincubated for 1 hr followed by EA addition and further incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA5156827 | B | Inhibition of recombinant human TTBK1 in ethacrynic acid-treated human SH-SY5Y cells assessed as nuclear localization by measuring reduction in cytosolic TDP-43 accumulation at 5 uM preincubated for 1 hr followed by EA addition and further incubated for 24 hrs by confocal laser scanning microscopy | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5156828 | F | Neuroprotective activity against okadaic acid-induced neurotoxicity in human SH-SY5Y cells assessed as reduction in Tau hyperphosphorylation by measuring cell viability at 1 to 5 uM incubated for 24 hrs by MTT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 9. | ALA5156829 | B | Inhibition of TTBK1 in Wistar rat primary microglia assessed as reduction in LPS-stimulated iNOS induction at 5 to 25 uM measured after 24 hrs by western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5156830 | B | Inhibition of TTBK1 in LPS-stimulated Wistar rat primary microglia assessed as increase in TREM2 expression at 5 to 25 uM measured after 24 hrs by western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5156831 | A | Tmax in BALB/c mouse plasma at 5 mg/kg, ip measured for 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5156832 | A | Tmax in BALB/c mouse brain at 5 mg/kg, ip measured for 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5156833 | A | Tmax in BALB/c mouse plasma at 10 mg/kg, po measured for 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5156834 | A | Tmax in BALB/c mouse brain at 10 mg/kg, po measured for 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5156835 | A | Cmax in BALB/c mouse plasma at 5 mg/kg, ip measured for 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5156836 | A | Cmax in BALB/c mouse brain at 5 mg/kg, ip measured for 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5156837 | A | Cmax in BALB/c mouse plasma at 10 mg/kg, po measured for 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5156838 | A | Cmax in BALB/c mouse brain at 10 mg/kg, po measured for 0.25 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5156839 | A | Half life in BALB/c mouse plasma at 5 mg/kg, ip measured for 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5156840 | A | AUClast in BALB/c mouse plasma at 5 mg/kg, ip measured for 0.08 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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