# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5142861 | B | Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-induced autophosphorylation at S2056 residue preincubated for 1 hr followed by 8 Gy irradiation and measured after 1 hr by ELISA | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
2. | ALA5142862 | B | Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate addition and further incubated for 40 mins in presence of ATP by TR-FRET assay | Homo sapiens | 19 | single protein format | Scientific Literature | ||
3. | ALA5142863 | P | 1-Octanol/aqueous buffer partition coefficient, logD of the compound at pH 7.4 by shake flask technique based UPLC analysis | 19 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA5142864 | T | Inhibition of hERG expressed in CHO cells by electrophysiological assay based automated patch clamp method | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
5. | ALA5142865 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance measured per mg of protein | Homo sapiens | 17 | microsome format | Scientific Literature | ||
6. | ALA5142869 | A | Plasma protein binding in human assessed as unbound fraction | Homo sapiens | 11 | cell-free format | Scientific Literature |