| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5115809 | B | Protac activity at CRBN/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as L858R/T790M mutant degradation at 0.03 to 3 uM incubated for 48 hrs by Western blot analysis relative to untreated control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5115836 | F | Anti-proliferative activity against human A549 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 3. | ALA5115837 | F | Anti-proliferative activity against human PC-9 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 4. | ALA5115838 | F | Anti-proliferative activity against human NCI-H1975 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 5. | ALA5115839 | B | Inhibition of wild type EGFR (unknown origin) incubated for 10 mins by HTRF KinEASE-TK assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 6. | ALA5115840 | B | Inhibition of EGFR L858R/T790M mutant (unknown origin) incubated for 35 mins by HTRF KinEASE-TK assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 7. | ALA5115841 | B | Selectivity index, ratio of IC50 for wild type EGFR (unknown origin) to IC50 for Protein cereblon/Epidermal growth factor receptor L858R/T790M mutant | Homo sapiens | 8 | assay format | Scientific Literature |
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