# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5124207 | Binding | Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method | Homo sapiens | 27 | ALA5120869 | cell-based format | Scientific Literature | |
2. | ALA5124208 | Binding | Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method | Homo sapiens | 27 | ALA5120869 | cell-based format | Scientific Literature | |
3. | ALA5124209 | ADME | Half life in CD1 mouse liver microsome at 1 uM in presence of NADPH incubated up to 60 mins by HPLC-MS/MS analysis | Mus musculus | 6 | ALA5120869 | microsome format | Scientific Literature | |
4. | ALA5124210 | ADME | Half life in Sprague-Dawley rat liver microsome at 1 uM in presence of NADPH incubated up to 60 mins by HPLC-MS/MS analysis | Rattus norvegicus | 6 | ALA5120869 | microsome format | Scientific Literature | |
5. | ALA5124211 | ADME | Half life in human liver microsome at 1 uM in presence of NADPH incubated up to 60 mins by HPLC-MS/MS analysis | Homo sapiens | 8 | ALA5120869 | microsome format | Scientific Literature | |
6. | ALA5124212 | ADME | Inhibition of CYP1A in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by phenacetin substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA5120869 | microsome format | Scientific Literature | |
7. | ALA5124213 | ADME | Inhibition of CYP2B6 in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by bupropion substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA5120869 | microsome format | Scientific Literature | |
8. | ALA5124214 | ADME | Inhibition of CYP2C8 in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by amodiaquine substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA5120869 | microsome format | Scientific Literature | |
9. | ALA5124215 | ADME | Inhibition of CYP2C9 in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by diclofenac substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA5120869 | microsome format | Scientific Literature | |
10. | ALA5124216 | ADME | Inhibition of CYP2C19 in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by omeprazole substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA5120869 | microsome format | Scientific Literature | |
11. | ALA5124217 | ADME | Inhibition of CYP2D6 in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by dextromethorphan substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA5120869 | microsome format | Scientific Literature | |
12. | ALA5124218 | ADME | Inhibition of CYP3A in human liver microsomes at 10 uM preincubated for 5 mins in presence of NADPH-generating system followed by midazolam substrate addition and measured after 10 mins by HPLC-MS/MS analysis relative to control | Homo sapiens | 5 | ALA5120869 | microsome format | Scientific Literature |