# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5168557 | T | Toxicity in SCID mouse xenografted with human HT cells assessed as body weight loss at 50 mg/kg, po bid measured upto 22 days | Mus musculus | 1 | ALA5154939 | organism-based format | Scientific Literature | |
2. | ALA5168558 | A | Free plasma concentration in SCID mouse at 50 mg/kg, po measured for 24 hrs | Mus musculus | 1 | ALA5154939 | organism-based format | Scientific Literature | |
3. | ALA5168559 | F | Downregulation of BCL6 levels in human OCI-Ly1 cells xenografted in SCID mouse at 50 mg/kg, po measured for 12 to 24 hrs by capillary electrophoresis method | Homo sapiens | 1 | ALA5154939 | organism-based format | Scientific Literature | |
4. | ALA5168560 | T | Toxicity in SCID mouse xenografted with human OCI-Ly1 cells assessed as noticeable adverse effects at 50 mg/kg, po measured for 12 to 24 hrs | Mus musculus | 1 | ALA5154939 | organism-based format | Scientific Literature | |
5. | ALA5168561 | A | Free drug concentration in SCID mouse blood at 50 mg/kg, po measured for 16 hrs | Mus musculus | 1 | ALA5154939 | organism-based format | Scientific Literature | |
6. | ALA5168562 | B | Inhibition of N-terminal thioredoxin-His6 tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI incubated for 2 hrs by TR-FRET assay | Homo sapiens | 20 | ALA5154939 | assay format | Scientific Literature | |
7. | ALA5168563 | B | Degradation of BCL6 in human OCI-Ly1 cells incubated for 2 hrs by MSD assay | Homo sapiens | 20 | ALA5154939 | cell-based format | Scientific Literature | |
8. | ALA5168564 | B | Degradation of BCL6 in human OCI-Ly1 cells assessed as maximal efficacy incubated for 2 hrs by MSD assay relative to control | Homo sapiens | 20 | ALA5154939 | cell-based format | Scientific Literature | |
9. | ALA5168565 | A | Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM preincubated for 10 mins and measured upto 30 mins in presence of NADPH measured per mg protein by UPLC based LCMS analysis | Mus musculus | 20 | ALA5154939 | microsome format | Scientific Literature | |
10. | ALA5168566 | P | Lipophilicity, logD of compound at pH 7.4 by UV-vis detection based HPLC analysis | 20 | ALA5154939 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA5168567 | P | Kinetic aqueous solubility of the compound in 4% DMSO/HEPES buffer at pH 8 incubated for 20 hrs by quantitative 1H-NMR analysis | 19 | ALA5154939 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA5168569 | A | Fraction unbound in IMDM medium at 5 uM incubated for 4 hrs by ESI-LCMS/MS based UPLC analysis | 4 | ALA5154939 | assay format | Scientific Literature | ||
13. | ALA5168570 | A | Intrinsic clearance in human liver microsomes at 1 uM preincubated for 10 mins and measured upto 30 mins in presence of NADPH measured per mg protein by UPLC based LCMS analysis | Homo sapiens | 5 | ALA5154939 | microsome format | Scientific Literature | |
14. | ALA5168571 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes at 1 uM preincubated for 10 mins and measured upto 30 mins in presence of NADPH measured per mg protein by UPLC based LCMS analysis | Rattus norvegicus | 5 | ALA5154939 | microsome format | Scientific Literature | |
15. | ALA5168572 | A | Passive membrane permeability of compound in phosphate buffered saline at pH 7.4 at 10 uM incubated for 16 hrs by PAMPA assay based TQ-S LC-MS/MS analysis | 5 | ALA5154939 | assay format | Scientific Literature | ||
16. | ALA5168573 | B | Degradation of BCL6 in human KARPAS-422 cells by MSD assay | Homo sapiens | 2 | ALA5154939 | cell-based format | Scientific Literature | |
17. | ALA5168574 | B | Degradation of BCL6 in human KARPAS-422 cells assessed as maximal efficacy by MSD assay relative to control | Homo sapiens | 1 | ALA5154939 | cell-based format | Scientific Literature | |
18. | ALA5168575 | F | Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay | Homo sapiens | 2 | ALA5154939 | cell-based format | Scientific Literature | |
19. | ALA5168576 | F | Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay | Homo sapiens | 2 | ALA5154939 | cell-based format | Scientific Literature | |
20. | ALA5168577 | F | Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay | Homo sapiens | 2 | ALA5154939 | cell-based format | Scientific Literature |
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