| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5158659 | F | Anti-fibrotic activity against unilateral ureteral obstruction kidney injury C57BL/6J mouse model assessed as inhibition of UUO-induced collagen IV mRNA expression in kidney administered intraperitoneally daily measured after 8 days by immunoblotting analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5158660 | F | Anti-fibrotic activity against unilateral ureteral obstruction kidney injury C57BL/6J mouse model assessed as inhibition of UUO-induced TGF-beta1 mRNA expression in kidney administered intraperitoneally daily measured after 8 days by immunoblotting analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA5158661 | F | Anti-fibrotic activity against unilateral ureteral obstruction kidney injury C57BL/6J mouse model assessed as inhibition of UUO-induced BRD4 mRNA expression in kidney at 15 to 30 mg/kg, ip administered daily measured at day 7 by RT-PCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA5158662 | A | Volume of distribution at steady state in ICR mouse at 2 mg/kg, iv measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA5158663 | B | Inhibition of His-tagged full length recombinant BRD4 (unknown origin) (21 to 153 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate measured after 1 hr by HTRF assay | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 6. | ALA5158664 | B | Inhibition of His-tagged recombinant BRD2 (unknown origin) (11 to 162 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate measured after 1 hr by HTRF assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA5158665 | B | Inhibition of His-tagged recombinant BRD3 (unknown origin) (11 to 166 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate measured after 1 hr by HTRF assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA5158666 | B | Inhibition of His-tagged recombinant BRDT (unknown origin) (21 to 153 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate measured after 1 hr by HTRF assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA5158667 | B | Inhibition of His-tagged recombinant BRPF3 (unknown origin) (11 to 188 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate measured after 1 hr by HTRF assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA5158668 | B | Inhibition of His-tagged recombinant BRD1 (unknown origin) (11 to 190 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as substrate measured after 1 hr by HTRF assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA5158669 | A | Clearance in ICR mouse at 2 mg/kg, iv measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5158670 | A | Half life in ICR mouse at 30 mg/kg, po measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5158671 | A | Tmax in ICR mouse at 30 mg/kg, po measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5158672 | A | Cmax in ICR mouse at 30 mg/kg, po measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5158673 | A | AUC (0 to t) in ICR mouse at 30 mg/kg, po measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5158674 | A | AUC (0 to infinity) in ICR mouse at 30 mg/kg, po measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5158675 | A | Oral bioavailability in ICR mouse at 30 mg/kg measured at 0.083 to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5158676 | F | Nephroprotective activity against unilateral ureteral obstruction kidney injury C57BL/6J mouse model assessed as decreased tubular injury score at 15 to 30 mg/kg, ip administered for 8 consecutive days by H & E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5158679 | F | Nephroprotective activity against unilateral ureteral obstruction kidney injury C57BL/6J mouse model assessed as decreased kidney damage at 15 to 30 mg/kg, ip administered for 8 consecutive days by H and E staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5158680 | F | Nephroprotective activity against unilateral ureteral obstruction kidney injury C57BL/6J mouse model assessed as decreased fibrotic scores at 15 to 30 mg/kg, ip administered for 8 consecutive days by Masson's staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature |
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