| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5118543 | Binding | Inhibition of FLT3 (unknown origin) preincubated with compound for 10 mins followed by substrate addition and measured after 1 hrs by ADP-Glo kinase assay | Homo sapiens | 8 | ALA5113503 | single protein format | Scientific Literature | |
| 2. | ALA5118544 | Binding | Inhibition of FLT3 (unknown origin) at 1 uM preincubated with compound for 10 mins followed by substrate addition and measured after 1 hrs by ADP-Glo kinase assay relative to control | Homo sapiens | 17 | ALA5113503 | single protein format | Scientific Literature | |
| 3. | ALA5118545 | Binding | Inhibition of FLT3-ITD mutant (unknown origin) at 1 uM preincubated with compound for 10 mins followed by substrate addition and measured after 1 hrs by ADP-Glo kinase assay relative to control | Homo sapiens | 17 | ALA5113503 | single protein format | Scientific Literature | |
| 4. | ALA5118546 | Functional | Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay | Homo sapiens | 17 | ALA5113503 | cell-based format | Scientific Literature | |
| 5. | ALA5118547 | Functional | Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition measured after 72 hrs by CCK8 assay | Homo sapiens | 17 | ALA5113503 | cell-based format | Scientific Literature | |
| 6. | ALA5118548 | Functional | Antiproliferative activity against human HL-60 cells harboring wildtype FLT3 assessed as cell growth inhibition measured after 72 hrs by CCK8 assay | Homo sapiens | 17 | ALA5113503 | cell-based format | Scientific Literature | |
| 7. | ALA5118549 | Functional | Antiproliferative activity activity human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay | Homo sapiens | 17 | ALA5113503 | cell-based format | Scientific Literature | |
| 8. | ALA5118550 | Functional | Antiproliferative activity activity human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay | Homo sapiens | 17 | ALA5113503 | cell-based format | Scientific Literature | |
| 9. | ALA5118551 | Toxicity | Cytotoxicity against HUVEC cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay | Homo sapiens | 17 | ALA5113503 | cell-based format | Scientific Literature | |
| 10. | ALA5118552 | Toxicity | Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay | Homo sapiens | 17 | ALA5113503 | cell-based format | Scientific Literature | |
| 11. | ALA5118553 | Functional | Induction of cell cycle arrest in human MV4-11 cells assessed as accumulation at G0/G1 phase at 0.1 uM measured after 24 hrs by flow cytometry (Rvb = 64.29 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 12. | ALA5118554 | Functional | Induction of cell cycle arrest in human MV4-11 cells assessed as accumulation at G0/G1 phase at 0.5 uM measured after 24 hrs by flow cytometry (Rvb = 64.29 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 13. | ALA5118555 | Functional | Induction of cell cycle arrest in human MV4-11 cells assessed as accumulation at G0/G1 phase at 2.5 uM measured after 24 hrs by flow cytometry (Rvb = 64.29 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 14. | ALA5118556 | Functional | Induction of apoptosis in human MV4-11 cells assessed as viable cells at 2.5 uM measured after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 80.26 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 15. | ALA5118557 | Functional | Induction of apoptosis in human MV4-11 cells assessed as early apoptotic cells at 2.5 uM measured after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 2.04 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 16. | ALA5118558 | Functional | Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 2.5 uM measured after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 12.03 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 17. | ALA5118559 | Functional | Induction of apoptosis in human MV4-11 cells assessed as necrotic cells at 2.5 uM measured after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 5.67 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 18. | ALA5118560 | Functional | Induction of apoptosis in human MV4-11 cells assessed as viable cells at 0.5 uM measured after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 80.26 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 19. | ALA5118561 | Functional | Induction of apoptosis in human MV4-11 cells assessed as early apoptotic cells at 0.5 uM measured after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 2.04 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature | |
| 20. | ALA5118562 | Functional | Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 0.5 uM measured after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 12.03 %) | Homo sapiens | 1 | ALA5113503 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!