# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5142716 | Functional | Anti-filarial activity against Onchocerca gutturosa adult worms assessed as reduction in worm motility measured every 24 hrs for 5 days by olympus inverted microscopic analysis | Onchocerca gutturosa | 60 | ALA5137098 | organism-based format | Scientific Literature | |
2. | ALA5142717 | Physicochemical | Kinetic solubility of compound incubated for 24 hrs | 59 | ALA5137098 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5142719 | ADME | Metabolic stability in rat liver microsome assessed as compound remaining at 3 uM measured at 30 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 8 | ALA5137098 | microsome format | Scientific Literature | |
4. | ALA5142721 | ADME | Metabolic stability in human liver microsome assessed as compound remaining at 3 uM measured at 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 9 | ALA5137098 | microsome format | Scientific Literature | |
5. | ALA5142728 | Functional | Antiparasitic activity against Litomosoides sigmodontis infected in BALB/c mouse assessed as reduction in worm burden at 30 mg/kg, po TID administered for 5 days | Litomosoides sigmodontis | 1 | ALA5137098 | organism-based format | Scientific Literature | |
6. | ALA5142736 | ADME | Cmax in CD-1 mouse at 30 mg/kg, po measured at 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 8 | ALA5137098 | organism-based format | Scientific Literature | |
7. | ALA5142739 | ADME | Tmax in CD-1 mouse at 30 mg/kg, po measured at 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 8 | ALA5137098 | organism-based format | Scientific Literature | |
8. | ALA5142742 | ADME | AUC (0 to infinity) in CD-1 mouse at 30 mg/kg, po measured at 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 8 | ALA5137098 | organism-based format | Scientific Literature |