# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5154217 | B | Inhibition of SARS-CoV-2 main protease at 10 uM using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 30 mins followed by substrate addition and measured every 10 sec for 10 mins by FRET assay relative to control | Severe acute respiratory syndrome coronavirus 2 | 33 | single protein format | Scientific Literature | ||
2. | ALA5154218 | B | Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 30 mins followed by substrate addition and measured every 10 sec for 10 mins by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 33 | single protein format | Scientific Literature | ||
3. | ALA5154219 | B | Potency index, ratio of IC50 for MCULE-5948770040 to IC50 for test compound for inhibition of SARS-COV-2 main protease | Severe acute respiratory syndrome coronavirus 2 | 2 | single protein format | Scientific Literature | ||
4. | ALA5154220 | F | Antiviral activity against SARS-CoV-2 infected in Vero E6 cells preincubated for 1 hr followed by methylcellulose addition and measured after 25 to 26 hrs by EliSpot reader based analysis | Severe acute respiratory syndrome coronavirus 2 | 7 | organism-based format | Scientific Literature | ||
5. | ALA5154221 | T | Cytotoxicity against african green monkey Vero E6 cells assessed as reduction in cell viability after 26 hrs by MTS assay | Chlorocebus sabaeus | 7 | cell-based format | Scientific Literature | ||
6. | ALA5154222 | B | Irreversible inhibition of SARS-CoV-2 main protease assessed as ratio of Kinact/Ki incubated for 60 mins by MS analysis | Severe acute respiratory syndrome coronavirus 2 | 1 | single protein format | Scientific Literature | ||
7. | ALA5154223 | B | Covalent inhibition of SARS-CoV-2 main protease assessed as protein-compound adduct formation incubated for 30 mins by MALDI-TOF analysis | Severe acute respiratory syndrome coronavirus 2 | 1 | single protein format | Scientific Literature | ||
8. | ALA5154224 | T | Inhibition of human cathepsin B using Z-Leu-Arg-AMC as substrate by FRET assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
9. | ALA5154225 | T | Inhibition of human cathepsin F using Z-Phe-Arg-AMC as substrate by FRET assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
10. | ALA5154226 | T | Inhibition of human cathepsin K using Ac-LR-AFC as substrate by FRET assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
11. | ALA5154227 | T | Inhibition of human cathepsin L using Z-Leu-Arg-AMC as substrate by FRET assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
12. | ALA5154228 | T | Inhibition of human caspase 3 using Ac-Asp-Glu-Val-Asp-pNA as substrate by FRET assay | Homo sapiens | 1 | assay format | Scientific Literature |