| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5139763 | B | Inhibition of N-terminal human TRKA (436 to 790 residues) expressed in baculovirus expression system using TK as substrate measured after 30 mins in presence of ATP by HTRF assay | Homo sapiens | 39 | assay format | Scientific Literature | ||
| 2. | ALA5139764 | B | Inhibition of N-terminal human TRKB (456 to 822 residues) expressed in baculovirus expression system using TK as substrate measured after 40 mins in presence of ATP by HTRF assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 3. | ALA5139765 | B | Inhibition of N-terminal human TRKC (456 to 825 residues) expressed in baculovirus expression system using TK as substrate measured after 40 mins in presence of ATP by HTRF assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 4. | ALA5139766 | A | Metabolic stability in human liver microsomes assessed as half life at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 5. | ALA5139767 | A | Metabolic stability in human microsomes assessed as intrinsic clearance at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 6. | ALA5139768 | A | Metabolic stability in human liver assessed as intrinsic clearance at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | tissue-based format | Scientific Literature | ||
| 7. | ALA5139769 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 100 uM incubated for 60 mins under shaking condition in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 8. | ALA5139770 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 100 uM incubated for 60 mins under shaking condition in absence of NADPH by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 9. | ALA5139771 | F | Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 10. | ALA5139772 | F | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 11. | ALA5139773 | F | Antiproliferative activity against human THLE-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA5139774 | F | Antiproliferative activity against mouse BaF3 cells harboring TRKA G595R mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Mus musculus | 9 | cell-based format | Scientific Literature | ||
| 13. | ALA5139775 | F | Antiproliferative activity against mouse BaF3 cells harboring TRKA G667C mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 14. | ALA5139776 | F | Antiproliferative activity against mouse BaF3 cells harboring TRKA F589L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA5139777 | F | Induction of apoptosis in human KM12 cells assessed as necrotic cells at 6.25 nM measured after 72 hrs by AnnexinV-FITC/PI staining based flowcytometry assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5139778 | F | Induction of apoptosis in human KM12 cells assessed as late apoptotic cells at 6.25 nM measured after 72 hrs by AnnexinV-FITC/PI staining based flowcytometry assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5139779 | F | Induction of apoptosis in human KM12 cells assessed as early apoptotic cells at 6.25 nM measured after 72 hrs by AnnexinV-FITC/PI staining based flowcytometry assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5139780 | F | Induction of apoptosis in human KM12 cells assessed as viable cells at 6.25 nM measured after 72 hrs by AnnexinV-FITC/PI staining based flowcytometry assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5139781 | F | Induction of apoptosis in human KM12 cells assessed as necrotic cells at 12.5 nM measured after 72 hrs by AnnexinV-FITC/PI staining based flowcytometry assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5139782 | F | Induction of apoptosis in human KM12 cells assessed as late apoptotic cells at 12.5 nM measured after 72 hrs by AnnexinV-FITC/PI staining based flowcytometry assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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