| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5126288 | B | Inhibition of His-tagged recombinant human Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 2. | ALA5126289 | B | Inhibition of His-tagged recombinant mouse Gal-3 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay | Mus musculus | 22 | single protein format | Scientific Literature | ||
| 3. | ALA5126292 | B | Inhibition of His-tagged recombinant human Gal-1 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 4. | ALA5126293 | B | Inhibition of His-tagged recombinant human Gal-9 preincubated for 30 mins followed by B-ASF addition measured after 1 hr by time resolved fluorescence based assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 5. | ALA5126294 | B | Selectivity ratio of IC50 for inhibition of His-tagged recombinant human Gal-1 to IC50 for inhibition of His-tagged recombinant human Gal-3 | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 6. | ALA5126295 | B | Selectivity ratio of IC50 for inhibition of His-tagged recombinant human Gal-9 to IC50 for inhibition of His-tagged recombinant human Gal-3 | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 7. | ALA5126296 | A | Metabolic stability of the compound in human liver microsomes assessed as CYP450-mediated metabolism by measuring parent compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 8. | ALA5126297 | A | Metabolic stability of the compound in rat liver microsomes assessed as CYP450-mediated metabolism by measuring parent compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 9. | ALA5126298 | A | Metabolic stability of the compound in mouse liver microsomes assessed as CYP450-mediated metabolism by measuring parent compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 10. | ALA5126299 | A | Protein binding in human serum at 10 uM incubated for 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 11. | ALA5126300 | A | Protein binding in rat serum at 10 uM incubated for 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 12. | ALA5126301 | A | Protein binding in mouse serum at 10 uM incubated for 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 13. | ALA5126302 | A | Cmax in C57BL6 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA5126303 | A | AUC (0 to 24 hrs) in C57BL6 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA5126304 | A | Clearance in C57BL6 mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA5126305 | A | Volume of distribution at steady state in C57BL6 mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA5126306 | A | Oral bioavailability in C57BL6 mouse at 10 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature |
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