# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5144471 | B | Inhibition of human recombinant MGMT expressed in Escherichia coli STAR BL21 pRare cells assessed as cleavage of fluorescent labelled substrate by Bsp 119I at 12.5 uM using O6MeG-bearing substrate (S) incubated for 5 mins by coupled enzymatic analysis relative to control | Homo sapiens | 14 | ALA5143526 | cell-based format | Scientific Literature | |
2. | ALA5144474 | B | Competitive inhibition of human recombinant MGMT expressed in Escherichia coli STAR BL21 pRare cells assessed as cleavage of fluorescent labelled substrate by Bsp 119I at 12.5 uM using O6MeG-bearing substrate (S) incubated for 10 mins in presence of non-substrate CT-DNA followed by substrate addition and measured after 5 mins by coupled enzymatic analysis | Homo sapiens | 7 | ALA5143526 | cell-based format | Scientific Literature | |
3. | ALA5144475 | F | Antiproliferative activity against human T98G cells assessed as cell growth inhibition incubated for 96 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 14 | ALA5143526 | cell-based format | Scientific Literature | |
4. | ALA5144504 | F | Additive antiproliferative activity against human T98G cells assessed as reduction in cell viability at GI50 pretreated for 2 hrs followed by TMZ addition at 188 uM and measured after 94 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 6 | ALA5143526 | cell-based format | Scientific Literature | |
5. | ALA5144508 | F | Additive antiproliferative activity against human T98G cells assessed as reduction in cell viability at GI50 pretreated for 2 hrs followed by TMZ addition at 375 uM and measured after 94 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 3 | ALA5143526 | cell-based format | Scientific Literature |